Ginkgolic acid C 17:1, derived from Ginkgo biloba leaves, suppresses constitutive and inducible STAT3 activation through induction of PTEN and SHP-1 tyrosine phosphatase

• Main Authors: Baek, S.H, Lee, J.H, Kim, C, Ko, J.-H, Ryu, S.-H, Lee, S.-G, Yang, W.M, Um, J.-Y, Chinnathambi, A, Alharbi, S.A, Sethi, G, Ahn, K.S, Choi, D.-K., Ganesan, P.
• Other Authors: DEPT OF PHARMACOLOGY
• Format: Article
• Published: MDPI AG 2020
• Subjects: ginkgolic acid; interleukin 6; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; plant extract; protein binding; protein tyrosine phosphatase SHP 1; salicylic acid derivative; STAT3 protein; agonists; apoptosis; cell cycle; cell proliferation; chemistry; drug effects; gene expression regulation; genetics; Ginkgo biloba; human; metabolism; mitochondrial membrane potential; multiple myeloma; phosphorylation; plant leaf; tumor cell line; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Interleukin-6; Membrane Potential, Mitochondrial; Multiple Myeloma; Phosphorylation; Plant Extracts; Plant Leaves; Protein Binding; Protein Tyrosine Phosphatase, Non-Receptor Type 6; PTEN Phosphohydrolase; Salicylates; STAT3 Transcription Factor
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179240
• Institution: National University of Singapore

10.3390/molecules22020276