VEGF regulates local inhibitory complement proteins in the eye and kidney

• Main Authors: Keir, L.S, Firth, R, Aponik, L, Feitelberg, D, Sakimoto, S, Aguilar, E, Welsh, G.I, Richards, A, Usui, Y, Satchell, S.C, Kuzmuk, V, Coward, R.J, Goult, J, Bull, K.R, Sharma, R, Bharti, K, Westenskow, P.D, Michael, I.P, Saleem, M.A, Friedlander, M
• Other Authors: MEDICINE
• Format: Article
• Published: American Society for Clinical Investigation 2020
• Subjects: complement; complement factor H; vasculotropin; vasculotropin receptor 2; CREB1 protein, human; Creb1 protein, mouse; cyclic AMP responsive element binding protein; eye protein; KDR protein, human; Kdr protein, mouse; PRKCA protein, human; Prkca protein, mouse; protein kinase C alpha; vascular endothelial growth factor A, mouse; vasculotropin A; VEGFA protein, human; age related macular degeneration; Article; choroid disease; comparative study; complement activation; complement alternative pathway; complement deposition; complement inhibition; controlled study; CRISPR Cas system; enzyme linked immunosorbent assay; epithelium cell; eye; genetic variability; HEK293 cell line; human; human cell; immunofluorescence; kidney; microvasculature; neovascularization (pathology); podocyte; priority journal; retinal pigment epithelium; thrombotic thrombocytopenic purpura; umbilical vein endothelial cell; Western blotting; aged; animal; antagonists and inhibitors; female; genetics; kidney disease; knockout mouse; macular degeneration; male; metabolism; mouse; pathology; Aged; Animals; Complement Factor H; Cyclic AMP Response Element-Binding Protein; Eye Proteins; Female; Humans; Kidney Diseases; Macular Degeneration; Male; Mice; Mice, Knockout; Podocytes; Protein Kinase C-alpha; Retinal Pigment Epithelium; Thrombotic Microangiopathies; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179248
• Institution: National University of Singapore

10.1172/JCI86418