Disease-linked mutations in factor H reveal pivotal role of cofactor activity in Self-surface–selective regulation of complement activation

Disease-linked mutations in factor H reveal pivotal role of cofactor activity in Self-surface–selective regulation of complement activation

10.1074/jbc.M117.795088

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Bibliographic Details
Main Authors:	Kerr, H, Wong, E, Makou, E, Yang, Y, Marchbank, K, Kavanagh, D, Richards, A, Herbert, A.P, Barlow, P.N
Other Authors:	MEDICINE
Format:	Article
Published:	American Society for Biochemistry and Molecular Biology Inc. 2020
Subjects:	Bins Blood Chemical activation Proteins Age-related macular degeneration Cofactor activity Complement activations Complement control proteins Complement systems Sheep erythrocytes Streptococcus pneumoniae Surface selectivity Disease control complement component C3b complement component C3d complement factor H sialic acid alternative complement pathway C3 C5 convertase bacterial protein CFI protein, human complement factor H, human complement factor I hybrid protein immobilized protein peptide fragment amino acid substitution amino terminal sequence animal cell Article binding affinity binding site biological activity carboxy terminal sequence CCP 1 gene complement activation complement mediated hemolysis controlled study decay accelerating activity disease linked mutation erythrocyte factor I cofactor activity gene gene mutation genetic association hemolysis hemolytic uremic syndrome Komagataella pastoris nonhuman priority journal protein cross linking protein domain protein function protein synthesis regulatory mechanism self surface selective regulation sheep structure activity relation surface property animal chemistry comparative study domestic sheep genetics human macular degeneration metabolism mutation solubility Amino Acid Substitution Animals Atypical Hemolytic Uremic Syndrome Bacterial Proteins Binding Sites Complement Activation Complement C3 Convertase, Alternative Pathway Complement C3d Complement Factor H Complement Factor I Erythrocytes Hemolysis Humans Immobilized Proteins Macular Degeneration Mutation Peptide Fragments Protein Interaction Domains and Motifs Recombinant Fusion Proteins Sheep, Domestic Solubility Surface Properties
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/179259
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Institution:	National University of Singapore

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https://scholarbank.nus.edu.sg/handle/10635/179259