Cavin-2 regulates the activity and stability of endothelial nitric-oxide synthase (eNOS) in angiogenesis

• Main Authors: Boopathy, G.T.K, Kulkarni, M, Ho, S.Y, Boey, A, Chua, E.W.M, Barathi, V.A, Carney, T.J, Wang, X, Hong, W
• Other Authors: CANCER SCIENCE INSTITUTE OF SINGAPORE
• Format: Article
• Published: American Society for Biochemistry and Molecular Biology Inc. 2020
• Subjects: Biosynthesis; Blood vessels; Cell membranes; Cell proliferation; Cells; Cytology; Diseases; Genes; Mass spectrometry; Nitric oxide; Age-related macular degeneration; Binding proteins; Electron microscopy analysis; Endothelial nitric-oxide synthase (eNOS); Oxygen induced retinopathies; Phosphatidylserine; Therapeutic strategy; Vessel formation; Endothelial cells; alpha5 integrin; angiopoietin 2; beta3 integrin; binding protein; caveolin 1; cavin 2; CD31 antigen; cell protein; collagen type 1; dectin 1; endoglin; endothelial nitric oxide synthase; ephrin receptor B4; fibroblast growth factor 2; gelatinase A; interleukin 7 receptor; membrane protein; messenger RNA; microsomal aminopeptidase; neuropilin 1; neuropilin 2; phosphatidylserine; prostaglandin G; protein kinase B; transforming growth factor beta; transforming growth factor beta2; tyrosine kinase receptor; unclassified drug; urokinase; vascular endothelial cadherin; cavin-2 protein, mouse; nitric oxide; Nos3 protein, mouse; zebrafish protein; angiogenesis; animal experiment; Article; caveola; cell invasion; cell migration; cell proliferation; CLEC14A gene; controlled study; electron microscopy; embryo; endothelial microparticle; enzyme activity; enzyme regulation; enzyme stability; exosome; flow cytometry; gene; gene expression; gene identification; genetic screening; human; human cell; IL7R gene; immunofluorescence; immunogold labeling; immunoprecipitation; mass spectrometry; microinjection; nonhuman; phenotype; priority journal; proliferative diabetic retinopathy; promoter region; protein analysis; protein expression; protein function; protein localization; protein secretion; quantitative analysis; real time polymerase chain reaction; retina development; retrolental fibroplasia; RNA splicing; RYK gene; SDPR gene; signal transduction; TINAGL1 gene; TMEM43 gene; TMEM59 gene; Western blotting; zebra fish; animal; disease model; genetics; metabolism; mouse; pathology; retina neovascularization; Animals; Disease Models, Animal; Enzyme Stability; Membrane Proteins; Mice; Nitric Oxide; Nitric Oxide Synthase Type III; Retinal Neovascularization; Retinopathy of Prematurity; Zebrafish; Zebrafish Proteins
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179254
• Institution: National University of Singapore

10.1074/jbc.M117.794743