Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein–Protein Interaction in Ovarian Cancer

• Main Authors: Wiedmann, M.M, Tan, Y.S, Wu, Y, Aibara, S, Xu, W, Sore, H.F, Verma, C.S, Itzhaki, L, Stewart, M, Brenton, J.D, Spring, D.R
• Other Authors: BIOLOGY (NU)
• Format: Article
• Published: Wiley-VCH Verlag 2020
• Subjects: Chemotherapy; Diseases; Drug products; Molecular dynamics; Transcription; Transcription factors; X ray crystallography; Crystallographic data; Drug discovery; Hepatocyte nuclear factors; Molecular dynamics simulations; Nuclear import; Peptide therapeutics; Peptidomimetics; Platinum-based chemotherapy; Peptides; cell penetrating peptide; protein binding; chemical structure; chemistry; drug effect; female; human; metabolism; molecular dynamics; molecular model; ovary tumor; Cell-Penetrating Peptides; Crystallography, X-Ray; Female; Humans; Models, Molecular; Molecular Dynamics Simulation; Molecular Structure; Ovarian Neoplasms; Protein Binding
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179270
• Institution: National University of Singapore

10.1002/anie.201609427