A rectal cancer feasibility study with an embedded phase III trial design assessing magnetic resonance tumour regression grade (mrTRG) as a novel biomarker to stratify management by good and poor response to chemoradiotherapy (TRIGGER): Study protocol for a randomised controlled trial
10.1186/s13063-017-2085-2
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2020
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sg-nus-scholar.10635-1794612024-04-25T02:39:15Z A rectal cancer feasibility study with an embedded phase III trial design assessing magnetic resonance tumour regression grade (mrTRG) as a novel biomarker to stratify management by good and poor response to chemoradiotherapy (TRIGGER): Study protocol for a randomised controlled trial Battersby, N.J Dattani, M Rao, S Cunningham, D Tait, D Adams, R Moran, B.J Khakoo, S Tekkis, P Rasheed, S Mirnezami, A Quirke, P West, N.P Nagtegaal, I Chong, I Sadanandam, A Valeri, N Thomas, K Frost, M Brown, G SURGERY capecitabine fluorouracil folinic acid oxaliplatin advanced cancer Article cancer grading cancer localization cancer survival cell density chemoradiotherapy controlled study drug toxicity feasibility study health economics human human cell human tissue intervention study magnetic resonance tumor regression grade morbidity multicenter study multiple cycle treatment nuclear magnetic resonance open study patient safety phase 3 clinical trial population research prospective study quality of life randomized controlled trial rectum cancer rectum carcinoma reproducibility treatment response tumor growth tumor regression unspecified side effect adenocarcinoma adjuvant chemoradiotherapy cancer grading clinical protocol clinical trial colostomy cost benefit analysis diagnostic imaging disease exacerbation disease free survival economics health care cost intention to treat analysis methodology mortality neoadjuvant therapy nuclear magnetic resonance imaging pathology predictive value rectum tumor secondary time factor treatment outcome tumor recurrence Adenocarcinoma Chemoradiotherapy, Adjuvant Clinical Protocols Colostomy Cost-Benefit Analysis Disease Progression Disease-Free Survival Feasibility Studies Health Care Costs Humans Intention to Treat Analysis Magnetic Resonance Imaging Neoadjuvant Therapy Neoplasm Grading Neoplasm Recurrence, Local Predictive Value of Tests Quality of Life Rectal Neoplasms Research Design Time Factors Treatment Outcome 10.1186/s13063-017-2085-2 Trials 18 1 394 2020-10-23T04:40:30Z 2020-10-23T04:40:30Z 2017 Article Battersby, N.J, Dattani, M, Rao, S, Cunningham, D, Tait, D, Adams, R, Moran, B.J, Khakoo, S, Tekkis, P, Rasheed, S, Mirnezami, A, Quirke, P, West, N.P, Nagtegaal, I, Chong, I, Sadanandam, A, Valeri, N, Thomas, K, Frost, M, Brown, G (2017). A rectal cancer feasibility study with an embedded phase III trial design assessing magnetic resonance tumour regression grade (mrTRG) as a novel biomarker to stratify management by good and poor response to chemoradiotherapy (TRIGGER): Study protocol for a randomised controlled trial. Trials 18 (1) : 394. ScholarBank@NUS Repository. https://doi.org/10.1186/s13063-017-2085-2 17456215 https://scholarbank.nus.edu.sg/handle/10635/179461 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031 |
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capecitabine fluorouracil folinic acid oxaliplatin advanced cancer Article cancer grading cancer localization cancer survival cell density chemoradiotherapy controlled study drug toxicity feasibility study health economics human human cell human tissue intervention study magnetic resonance tumor regression grade morbidity multicenter study multiple cycle treatment nuclear magnetic resonance open study patient safety phase 3 clinical trial population research prospective study quality of life randomized controlled trial rectum cancer rectum carcinoma reproducibility treatment response tumor growth tumor regression unspecified side effect adenocarcinoma adjuvant chemoradiotherapy cancer grading clinical protocol clinical trial colostomy cost benefit analysis diagnostic imaging disease exacerbation disease free survival economics health care cost intention to treat analysis methodology mortality neoadjuvant therapy nuclear magnetic resonance imaging pathology predictive value rectum tumor secondary time factor treatment outcome tumor recurrence Adenocarcinoma Chemoradiotherapy, Adjuvant Clinical Protocols Colostomy Cost-Benefit Analysis Disease Progression Disease-Free Survival Feasibility Studies Health Care Costs Humans Intention to Treat Analysis Magnetic Resonance Imaging Neoadjuvant Therapy Neoplasm Grading Neoplasm Recurrence, Local Predictive Value of Tests Quality of Life Rectal Neoplasms Research Design Time Factors Treatment Outcome |
| spellingShingle |
capecitabine fluorouracil folinic acid oxaliplatin advanced cancer Article cancer grading cancer localization cancer survival cell density chemoradiotherapy controlled study drug toxicity feasibility study health economics human human cell human tissue intervention study magnetic resonance tumor regression grade morbidity multicenter study multiple cycle treatment nuclear magnetic resonance open study patient safety phase 3 clinical trial population research prospective study quality of life randomized controlled trial rectum cancer rectum carcinoma reproducibility treatment response tumor growth tumor regression unspecified side effect adenocarcinoma adjuvant chemoradiotherapy cancer grading clinical protocol clinical trial colostomy cost benefit analysis diagnostic imaging disease exacerbation disease free survival economics health care cost intention to treat analysis methodology mortality neoadjuvant therapy nuclear magnetic resonance imaging pathology predictive value rectum tumor secondary time factor treatment outcome tumor recurrence Adenocarcinoma Chemoradiotherapy, Adjuvant Clinical Protocols Colostomy Cost-Benefit Analysis Disease Progression Disease-Free Survival Feasibility Studies Health Care Costs Humans Intention to Treat Analysis Magnetic Resonance Imaging Neoadjuvant Therapy Neoplasm Grading Neoplasm Recurrence, Local Predictive Value of Tests Quality of Life Rectal Neoplasms Research Design Time Factors Treatment Outcome Battersby, N.J Dattani, M Rao, S Cunningham, D Tait, D Adams, R Moran, B.J Khakoo, S Tekkis, P Rasheed, S Mirnezami, A Quirke, P West, N.P Nagtegaal, I Chong, I Sadanandam, A Valeri, N Thomas, K Frost, M Brown, G A rectal cancer feasibility study with an embedded phase III trial design assessing magnetic resonance tumour regression grade (mrTRG) as a novel biomarker to stratify management by good and poor response to chemoradiotherapy (TRIGGER): Study protocol for a randomised controlled trial |
| description |
10.1186/s13063-017-2085-2 |
| author2 |
SURGERY |
| author_facet |
SURGERY Battersby, N.J Dattani, M Rao, S Cunningham, D Tait, D Adams, R Moran, B.J Khakoo, S Tekkis, P Rasheed, S Mirnezami, A Quirke, P West, N.P Nagtegaal, I Chong, I Sadanandam, A Valeri, N Thomas, K Frost, M Brown, G |
| format |
Article |
| author |
Battersby, N.J Dattani, M Rao, S Cunningham, D Tait, D Adams, R Moran, B.J Khakoo, S Tekkis, P Rasheed, S Mirnezami, A Quirke, P West, N.P Nagtegaal, I Chong, I Sadanandam, A Valeri, N Thomas, K Frost, M Brown, G |
| author_sort |
Battersby, N.J |
| title |
A rectal cancer feasibility study with an embedded phase III trial design assessing magnetic resonance tumour regression grade (mrTRG) as a novel biomarker to stratify management by good and poor response to chemoradiotherapy (TRIGGER): Study protocol for a randomised controlled trial |
| title_short |
A rectal cancer feasibility study with an embedded phase III trial design assessing magnetic resonance tumour regression grade (mrTRG) as a novel biomarker to stratify management by good and poor response to chemoradiotherapy (TRIGGER): Study protocol for a randomised controlled trial |
| title_full |
A rectal cancer feasibility study with an embedded phase III trial design assessing magnetic resonance tumour regression grade (mrTRG) as a novel biomarker to stratify management by good and poor response to chemoradiotherapy (TRIGGER): Study protocol for a randomised controlled trial |
| title_fullStr |
A rectal cancer feasibility study with an embedded phase III trial design assessing magnetic resonance tumour regression grade (mrTRG) as a novel biomarker to stratify management by good and poor response to chemoradiotherapy (TRIGGER): Study protocol for a randomised controlled trial |
| title_full_unstemmed |
A rectal cancer feasibility study with an embedded phase III trial design assessing magnetic resonance tumour regression grade (mrTRG) as a novel biomarker to stratify management by good and poor response to chemoradiotherapy (TRIGGER): Study protocol for a randomised controlled trial |
| title_sort |
rectal cancer feasibility study with an embedded phase iii trial design assessing magnetic resonance tumour regression grade (mrtrg) as a novel biomarker to stratify management by good and poor response to chemoradiotherapy (trigger): study protocol for a randomised controlled trial |
| publishDate |
2020 |
| url |
https://scholarbank.nus.edu.sg/handle/10635/179461 |
| _version_ |
1800914551145758720 |