A rectal cancer feasibility study with an embedded phase III trial design assessing magnetic resonance tumour regression grade (mrTRG) as a novel biomarker to stratify management by good and poor response to chemoradiotherapy (TRIGGER): Study protocol for a randomised controlled trial

A rectal cancer feasibility study with an embedded phase III trial design assessing magnetic resonance tumour regression grade (mrTRG) as a novel biomarker to stratify management by good and poor response to chemoradiotherapy (TRIGGER): Study protocol for a randomised controlled trial

10.1186/s13063-017-2085-2

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Bibliographic Details
Main Authors:	Battersby, N.J, Dattani, M, Rao, S, Cunningham, D, Tait, D, Adams, R, Moran, B.J, Khakoo, S, Tekkis, P, Rasheed, S, Mirnezami, A, Quirke, P, West, N.P, Nagtegaal, I, Chong, I, Sadanandam, A, Valeri, N, Thomas, K, Frost, M, Brown, G
Other Authors:	SURGERY
Format:	Article
Published:	2020
Subjects:	capecitabine fluorouracil folinic acid oxaliplatin advanced cancer Article cancer grading cancer localization cancer survival cell density chemoradiotherapy controlled study drug toxicity feasibility study health economics human human cell human tissue intervention study magnetic resonance tumor regression grade morbidity multicenter study multiple cycle treatment nuclear magnetic resonance open study patient safety phase 3 clinical trial population research prospective study quality of life randomized controlled trial rectum cancer rectum carcinoma reproducibility treatment response tumor growth tumor regression unspecified side effect adenocarcinoma adjuvant chemoradiotherapy clinical protocol clinical trial colostomy cost benefit analysis diagnostic imaging disease exacerbation disease free survival economics health care cost intention to treat analysis methodology mortality neoadjuvant therapy nuclear magnetic resonance imaging pathology predictive value rectum tumor secondary time factor treatment outcome tumor recurrence Adenocarcinoma Chemoradiotherapy, Adjuvant Clinical Protocols Colostomy Cost-Benefit Analysis Disease Progression Disease-Free Survival Feasibility Studies Health Care Costs Humans Intention to Treat Analysis Magnetic Resonance Imaging Neoadjuvant Therapy Neoplasm Grading Neoplasm Recurrence, Local Predictive Value of Tests Quality of Life Rectal Neoplasms Research Design Time Factors Treatment Outcome
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/179461
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Institution:	National University of Singapore

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