PI4 kinase is a prophylactic but not radical curative target in Plasmodium vivax-type malaria parasites

• Main Authors: Zeeman, A.-M, Lakshminarayana, S.B, Van Der Werff, N, Klooster, E.J, Voorberg-Van Der Wel, A, Kondreddi, R.R, Bodenreider, C, Simon, O, Sauerwein, R, Yeung, B.K.S, Diagana, T.T, Kocken, C.H.M
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: American Society for Microbiology 2020
• Subjects: antimalarial agent; bilirubin; chloroquine; gamma glutamyltransferase; kdu 691; lmv 599; phosphatidylinositol kinase; phosphotransferase inhibitor; unclassified drug; animal experiment; animal model; animal tissue; area under the curve; Article; bilirubin blood level; controlled study; drug bioavailability; drug blood level; drug efficacy; gamma glutamyl transferase blood level; IC50; in vitro study; in vivo study; liver; liver function; malaria; malaria control; maximum plasma concentration; multiple drug dose; nonhuman; plasma concentration-time curve; Plasmodium cynomolgi; Plasmodium cynomolgi malaria; priority journal; protein targeting; rhesus monkey; secondary infection; single drug dose; skin color; sporozoite; statistical significance; animal; drug effects; Malaria, Vivax; mouse; parasitemia; parasitology; pathogenicity; Plasmodium vivax; Animals; Antimalarials; Macaca mulatta; Mice; Parasitemia; Sporozoites
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179577
• Institution: National University of Singapore

10.1128/AAC.03080-15