PI4 kinase is a prophylactic but not radical curative target in Plasmodium vivax-type malaria parasites

10.1128/AAC.03080-15

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Main Authors:	Zeeman, A.-M, Lakshminarayana, S.B, Van Der Werff, N, Klooster, E.J, Voorberg-Van Der Wel, A, Kondreddi, R.R, Bodenreider, C, Simon, O, Sauerwein, R, Yeung, B.K.S, Diagana, T.T, Kocken, C.H.M
Other Authors:	MICROBIOLOGY AND IMMUNOLOGY
Format:	Article
Published:	American Society for Microbiology 2020
Subjects:	antimalarial agent bilirubin chloroquine gamma glutamyltransferase kdu 691 lmv 599 phosphatidylinositol kinase phosphotransferase inhibitor unclassified drug animal experiment animal model animal tissue area under the curve Article bilirubin blood level controlled study drug bioavailability drug blood level drug efficacy gamma glutamyl transferase blood level IC50 in vitro study in vivo study liver liver function malaria malaria control maximum plasma concentration multiple drug dose nonhuman plasma concentration-time curve Plasmodium cynomolgi Plasmodium cynomolgi malaria priority journal protein targeting rhesus monkey secondary infection single drug dose skin color sporozoite statistical significance animal drug effects Malaria, Vivax mouse parasitemia parasitology pathogenicity Plasmodium vivax Animals Antimalarials Macaca mulatta Mice Parasitemia Sporozoites
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/179577
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1795772024-03-27T08:13:38Z PI4 kinase is a prophylactic but not radical curative target in Plasmodium vivax-type malaria parasites Zeeman, A.-M Lakshminarayana, S.B Van Der Werff, N Klooster, E.J Voorberg-Van Der Wel, A Kondreddi, R.R Bodenreider, C Simon, O Sauerwein, R Yeung, B.K.S Diagana, T.T Kocken, C.H.M MICROBIOLOGY AND IMMUNOLOGY antimalarial agent bilirubin chloroquine gamma glutamyltransferase kdu 691 lmv 599 phosphatidylinositol kinase phosphotransferase inhibitor unclassified drug antimalarial agent animal experiment animal model animal tissue area under the curve Article bilirubin blood level controlled study drug bioavailability drug blood level drug efficacy gamma glutamyl transferase blood level IC50 in vitro study in vivo study liver liver function malaria malaria control maximum plasma concentration multiple drug dose nonhuman plasma concentration-time curve Plasmodium cynomolgi Plasmodium cynomolgi malaria priority journal protein targeting rhesus monkey secondary infection single drug dose skin color sporozoite statistical significance animal drug effects Malaria, Vivax mouse parasitemia parasitology pathogenicity Plasmodium vivax Animals Antimalarials Macaca mulatta Malaria, Vivax Mice Parasitemia Plasmodium vivax Sporozoites 10.1128/AAC.03080-15 Antimicrobial Agents and Chemotherapy 60 5 2858-2863 2020-10-23T07:55:21Z 2020-10-23T07:55:21Z 2016 Article Zeeman, A.-M, Lakshminarayana, S.B, Van Der Werff, N, Klooster, E.J, Voorberg-Van Der Wel, A, Kondreddi, R.R, Bodenreider, C, Simon, O, Sauerwein, R, Yeung, B.K.S, Diagana, T.T, Kocken, C.H.M (2016). PI4 kinase is a prophylactic but not radical curative target in Plasmodium vivax-type malaria parasites. Antimicrobial Agents and Chemotherapy 60 (5) : 2858-2863. ScholarBank@NUS Repository. https://doi.org/10.1128/AAC.03080-15 0066-4804 https://scholarbank.nus.edu.sg/handle/10635/179577 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ American Society for Microbiology Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	antimalarial agent bilirubin chloroquine gamma glutamyltransferase kdu 691 lmv 599 phosphatidylinositol kinase phosphotransferase inhibitor unclassified drug antimalarial agent animal experiment animal model animal tissue area under the curve Article bilirubin blood level controlled study drug bioavailability drug blood level drug efficacy gamma glutamyl transferase blood level IC50 in vitro study in vivo study liver liver function malaria malaria control maximum plasma concentration multiple drug dose nonhuman plasma concentration-time curve Plasmodium cynomolgi Plasmodium cynomolgi malaria priority journal protein targeting rhesus monkey secondary infection single drug dose skin color sporozoite statistical significance animal drug effects Malaria, Vivax mouse parasitemia parasitology pathogenicity Plasmodium vivax Animals Antimalarials Macaca mulatta Malaria, Vivax Mice Parasitemia Plasmodium vivax Sporozoites
spellingShingle	antimalarial agent bilirubin chloroquine gamma glutamyltransferase kdu 691 lmv 599 phosphatidylinositol kinase phosphotransferase inhibitor unclassified drug antimalarial agent animal experiment animal model animal tissue area under the curve Article bilirubin blood level controlled study drug bioavailability drug blood level drug efficacy gamma glutamyl transferase blood level IC50 in vitro study in vivo study liver liver function malaria malaria control maximum plasma concentration multiple drug dose nonhuman plasma concentration-time curve Plasmodium cynomolgi Plasmodium cynomolgi malaria priority journal protein targeting rhesus monkey secondary infection single drug dose skin color sporozoite statistical significance animal drug effects Malaria, Vivax mouse parasitemia parasitology pathogenicity Plasmodium vivax Animals Antimalarials Macaca mulatta Malaria, Vivax Mice Parasitemia Plasmodium vivax Sporozoites Zeeman, A.-M Lakshminarayana, S.B Van Der Werff, N Klooster, E.J Voorberg-Van Der Wel, A Kondreddi, R.R Bodenreider, C Simon, O Sauerwein, R Yeung, B.K.S Diagana, T.T Kocken, C.H.M PI4 kinase is a prophylactic but not radical curative target in Plasmodium vivax-type malaria parasites
description	10.1128/AAC.03080-15
author2	MICROBIOLOGY AND IMMUNOLOGY
author_facet	MICROBIOLOGY AND IMMUNOLOGY Zeeman, A.-M Lakshminarayana, S.B Van Der Werff, N Klooster, E.J Voorberg-Van Der Wel, A Kondreddi, R.R Bodenreider, C Simon, O Sauerwein, R Yeung, B.K.S Diagana, T.T Kocken, C.H.M
format	Article
author	Zeeman, A.-M Lakshminarayana, S.B Van Der Werff, N Klooster, E.J Voorberg-Van Der Wel, A Kondreddi, R.R Bodenreider, C Simon, O Sauerwein, R Yeung, B.K.S Diagana, T.T Kocken, C.H.M
author_sort	Zeeman, A.-M
title	PI4 kinase is a prophylactic but not radical curative target in Plasmodium vivax-type malaria parasites
title_short	PI4 kinase is a prophylactic but not radical curative target in Plasmodium vivax-type malaria parasites
title_full	PI4 kinase is a prophylactic but not radical curative target in Plasmodium vivax-type malaria parasites
title_fullStr	PI4 kinase is a prophylactic but not radical curative target in Plasmodium vivax-type malaria parasites
title_full_unstemmed	PI4 kinase is a prophylactic but not radical curative target in Plasmodium vivax-type malaria parasites
title_sort	pi4 kinase is a prophylactic but not radical curative target in plasmodium vivax-type malaria parasites
publisher	American Society for Microbiology
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/179577
_version_	1795301250600796160

PI4 kinase is a prophylactic but not radical curative target in Plasmodium vivax-type malaria parasites

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