Functional evolution in orthologous cell-encoded RNA-dependent RNA polymerases

• Main Authors: Qian, X, Hamid, F.M, El Sahili, A, Darwis, D.A, Wong, Y.H, Bhushan, S, Makeyev, E.V, Lescar, J
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: American Society for Biochemistry and Molecular Biology Inc. 2020
• Subjects: Biology; Crystal structure; Genes; Polymers; Amino acid sequence; Electron microscopy analysis; Enzymatic activities; Eukaryotic organisms; Functional changes; Myceliophthora thermophila; Quaternary structure; RNA-dependent RNA polymerase; RNA; alanine; aspartic acid; RNA directed RNA polymerase; fungal protein; amino acid sequence; amino acid substitution; Article; controlled study; crystal structure; dimerization; electron microscopy; enzyme active site; enzyme activity; enzyme conformation; evolution; fungal gene; fungus; genetic analysis; Neurospora crassa; nonhuman; orthology; priority journal; protein binding; protein folding; protein function; protein purification; protein quaternary structure; protein structure; RNA synthesis; thermostability; Thielavia terrestris; chemistry; enzymology; genetics; metabolism; molecular evolution; physiology; protein multimerization; X ray crystallography; Crystallography, X-Ray; Evolution, Molecular; Fungal Proteins; Protein Multimerization; Protein Structure, Quaternary; RNA Replicase
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179581
• Institution: National University of Singapore

10.1074/jbc.M115.685933