Functional evolution in orthologous cell-encoded RNA-dependent RNA polymerases

10.1074/jbc.M115.685933

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Main Authors:	Qian, X, Hamid, F.M, El Sahili, A, Darwis, D.A, Wong, Y.H, Bhushan, S, Makeyev, E.V, Lescar, J
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	American Society for Biochemistry and Molecular Biology Inc. 2020
Subjects:	Biology Crystal structure Genes Polymers Amino acid sequence Electron microscopy analysis Enzymatic activities Eukaryotic organisms Functional changes Myceliophthora thermophila Quaternary structure RNA-dependent RNA polymerase RNA alanine aspartic acid RNA directed RNA polymerase fungal protein amino acid sequence amino acid substitution Article controlled study crystal structure dimerization electron microscopy enzyme active site enzyme activity enzyme conformation evolution fungal gene fungus genetic analysis Neurospora crassa nonhuman orthology priority journal protein binding protein folding protein function protein purification protein quaternary structure protein structure RNA synthesis thermostability Thielavia terrestris chemistry enzymology genetics metabolism molecular evolution physiology protein multimerization X ray crystallography Crystallography, X-Ray Evolution, Molecular Fungal Proteins Protein Multimerization Protein Structure, Quaternary RNA Replicase
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/179581
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1795812024-11-14T04:05:11Z Functional evolution in orthologous cell-encoded RNA-dependent RNA polymerases Qian, X Hamid, F.M El Sahili, A Darwis, D.A Wong, Y.H Bhushan, S Makeyev, E.V Lescar, J DUKE-NUS MEDICAL SCHOOL Biology Crystal structure Genes Polymers Amino acid sequence Electron microscopy analysis Enzymatic activities Eukaryotic organisms Functional changes Myceliophthora thermophila Quaternary structure RNA-dependent RNA polymerase RNA alanine aspartic acid RNA directed RNA polymerase fungal protein RNA directed RNA polymerase amino acid sequence amino acid substitution Article controlled study crystal structure dimerization electron microscopy enzyme active site enzyme activity enzyme conformation evolution fungal gene fungus genetic analysis Myceliophthora thermophila Neurospora crassa nonhuman orthology priority journal protein binding protein folding protein function protein purification protein quaternary structure protein structure RNA synthesis thermostability Thielavia terrestris chemistry enzymology genetics metabolism molecular evolution Neurospora crassa physiology protein multimerization X ray crystallography Crystallography, X-Ray Evolution, Molecular Fungal Proteins Neurospora crassa Protein Multimerization Protein Structure, Quaternary RNA Replicase 10.1074/jbc.M115.685933 Journal of Biological Chemistry 291 17 9295-9309 2020-10-23T07:56:09Z 2020-10-23T07:56:09Z 2016 Article Qian, X, Hamid, F.M, El Sahili, A, Darwis, D.A, Wong, Y.H, Bhushan, S, Makeyev, E.V, Lescar, J (2016). Functional evolution in orthologous cell-encoded RNA-dependent RNA polymerases. Journal of Biological Chemistry 291 (17) : 9295-9309. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M115.685933 0021-9258 https://scholarbank.nus.edu.sg/handle/10635/179581 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ American Society for Biochemistry and Molecular Biology Inc. Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	Biology Crystal structure Genes Polymers Amino acid sequence Electron microscopy analysis Enzymatic activities Eukaryotic organisms Functional changes Myceliophthora thermophila Quaternary structure RNA-dependent RNA polymerase RNA alanine aspartic acid RNA directed RNA polymerase fungal protein RNA directed RNA polymerase amino acid sequence amino acid substitution Article controlled study crystal structure dimerization electron microscopy enzyme active site enzyme activity enzyme conformation evolution fungal gene fungus genetic analysis Myceliophthora thermophila Neurospora crassa nonhuman orthology priority journal protein binding protein folding protein function protein purification protein quaternary structure protein structure RNA synthesis thermostability Thielavia terrestris chemistry enzymology genetics metabolism molecular evolution Neurospora crassa physiology protein multimerization X ray crystallography Crystallography, X-Ray Evolution, Molecular Fungal Proteins Neurospora crassa Protein Multimerization Protein Structure, Quaternary RNA Replicase
spellingShingle	Biology Crystal structure Genes Polymers Amino acid sequence Electron microscopy analysis Enzymatic activities Eukaryotic organisms Functional changes Myceliophthora thermophila Quaternary structure RNA-dependent RNA polymerase RNA alanine aspartic acid RNA directed RNA polymerase fungal protein RNA directed RNA polymerase amino acid sequence amino acid substitution Article controlled study crystal structure dimerization electron microscopy enzyme active site enzyme activity enzyme conformation evolution fungal gene fungus genetic analysis Myceliophthora thermophila Neurospora crassa nonhuman orthology priority journal protein binding protein folding protein function protein purification protein quaternary structure protein structure RNA synthesis thermostability Thielavia terrestris chemistry enzymology genetics metabolism molecular evolution Neurospora crassa physiology protein multimerization X ray crystallography Crystallography, X-Ray Evolution, Molecular Fungal Proteins Neurospora crassa Protein Multimerization Protein Structure, Quaternary RNA Replicase Qian, X Hamid, F.M El Sahili, A Darwis, D.A Wong, Y.H Bhushan, S Makeyev, E.V Lescar, J Functional evolution in orthologous cell-encoded RNA-dependent RNA polymerases
description	10.1074/jbc.M115.685933
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Qian, X Hamid, F.M El Sahili, A Darwis, D.A Wong, Y.H Bhushan, S Makeyev, E.V Lescar, J
format	Article
author	Qian, X Hamid, F.M El Sahili, A Darwis, D.A Wong, Y.H Bhushan, S Makeyev, E.V Lescar, J
author_sort	Qian, X
title	Functional evolution in orthologous cell-encoded RNA-dependent RNA polymerases
title_short	Functional evolution in orthologous cell-encoded RNA-dependent RNA polymerases
title_full	Functional evolution in orthologous cell-encoded RNA-dependent RNA polymerases
title_fullStr	Functional evolution in orthologous cell-encoded RNA-dependent RNA polymerases
title_full_unstemmed	Functional evolution in orthologous cell-encoded RNA-dependent RNA polymerases
title_sort	functional evolution in orthologous cell-encoded rna-dependent rna polymerases
publisher	American Society for Biochemistry and Molecular Biology Inc.
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/179581
_version_	1821199633571905536

Functional evolution in orthologous cell-encoded RNA-dependent RNA polymerases

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