Pharmacological actions of nobiletin in the modulation of platelet function

• Main Authors: Vaiyapuri, S, Roweth, H, Ali, M.S, Unsworth, A.J, Stainer, A.R, Flora, G.D, Crescente, M, Jones, C.I, Moraes, L.A, Gibbins, J.M
• Other Authors: PHYSIOLOGY
• Format: Article
• Published: John Wiley and Sons Inc. 2020
• Subjects: calcium; cyclic GMP; cyclic nucleotide; fibrinogen; glycoprotein; glycoprotein VI; integrin; integrin alpha2beta3; nobiletin; phospholipase C gamma2; phosphoprotein; protein kinase B; unclassified drug; fibrinogen receptor; flavone derivative; aggregometry; animal cell; Article; binding affinity; binding site; bleeding time; blood clotting; calcium mobilization; controlled study; drug effect; drug mechanism; drug potency; enzyme inactivation; enzyme phosphorylation; homeostasis; human; human cell; in vitro study; in vivo study; measurement; molecular dynamics; mouse; nonhuman; priority journal; protein binding; protein phosphorylation; signal transduction; thrombocyte aggregation; thrombocyte function; animal; blood clotting test; C57BL mouse; cell culture; chemically induced; drug effects; metabolism; physiology; thrombocyte; thrombocyte activation; thrombosis; Animals; Blood Coagulation Tests; Blood Platelets; Calcium; Cells, Cultured; Cyclic GMP; Fibrinogen; Flavones; Humans; Mice, Inbred C57BL; Platelet Activation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Proto-Oncogene Proteins c-akt; Thrombosis
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179655
• Institution: National University of Singapore

10.1111/bph.13191