Overexpression of SOX4 correlates with poor prognosis of acute myeloid leukemia and is leukemogenic in zebrafish

• Main Authors: Lu, J.-W, Hsieh, M.-S, Hou, H.-A, Chen, C.-Y, Tien, H.-F, Lin, L.-I
• Other Authors: BIOLOGICAL SCIENCES
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: CD135 antigen; messenger RNA; nucleophosmin; transcription factor Sox4; transcription factor Sox; tumor protein; zebrafish protein; acute myeloid leukemia; adult; animal experiment; animal model; animal tissue; Article; bone marrow cell; cancer patient; cancer prognosis; cell dedifferentiation; cell infiltration; controlled study; de novo acute myeloid leukemia; disease free survival; embryo; follow up; human; immunocytochemistry; in situ hybridization; induction chemotherapy; karyotype; karyotyping; kidney structure; leukemogenesis; leukocyte count; major clinical study; microscopy; myeloid progenitor cell; myelopoiesis; nonhuman; overall survival; patient; polymerase chain reaction; protein expression; quantitative analysis; remission; reverse transcription polymerase chain reaction; tissue section; zebra fish; animal; biosynthesis; gene expression regulation; genetics; metabolism; pathology; transgenic animal; Animals; Animals, Genetically Modified; Gene Expression Regulation, Neoplastic; Leukemia, Myeloid, Acute; Myelopoiesis; Neoplasm Proteins; SOXC Transcription Factors; Zebrafish; Zebrafish Proteins
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179702
• Institution: National University of Singapore

10.1038/bcj.2017.74