MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells

• Main Authors: Lai, X, Broderick, R, Bergoglio, V, Zimmer, J, Badie, S, Niedzwiedz, W, Hoffmann, J.-S, Tarsounas, M
• Other Authors: CANCER SCIENCE INSTITUTE OF SINGAPORE
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: BRCA2 protein; DNA; endonuclease; MUS81 endonuclease; protein SLX4; scaffold protein; small interfering RNA; unclassified drug; BRCA2 protein, human; DNA binding protein; MUS81 protein, human; cells and cell components; chromosome; environmental stress; enzyme activity; gene; genome; lesion; tolerance; anaphase; Article; cell stress; cell survival; chromosome segregation; controlled study; cytokinesis; DNA damage; DNA replication; DNA synthesis; enzyme inhibition; female; G1 phase cell cycle checkpoint; genetic transfection; human; human cell; mitosis; protein depletion; protein expression; protein protein interaction; genetics; HeLa cell line; metabolism; tumor cell line; Anaphase; BRCA2 Protein; Cell Line, Tumor; Chromosome Segregation; DNA Damage; DNA Replication; DNA-Binding Proteins; Endonucleases; HeLa Cells; Humans; Mitosis
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179707
• Institution: National University of Singapore

10.1038/ncomms15983