MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells

10.1038/ncomms15983

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Main Authors:	Lai, X, Broderick, R, Bergoglio, V, Zimmer, J, Badie, S, Niedzwiedz, W, Hoffmann, J.-S, Tarsounas, M
Other Authors:	CANCER SCIENCE INSTITUTE OF SINGAPORE
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	BRCA2 protein DNA endonuclease MUS81 endonuclease protein SLX4 scaffold protein small interfering RNA unclassified drug BRCA2 protein, human DNA binding protein MUS81 protein, human cells and cell components chromosome environmental stress enzyme activity gene genome lesion tolerance anaphase Article cell stress cell survival chromosome segregation controlled study cytokinesis DNA damage DNA replication DNA synthesis enzyme inhibition female G1 phase cell cycle checkpoint genetic transfection human human cell mitosis protein depletion protein expression protein protein interaction genetics HeLa cell line metabolism tumor cell line Anaphase BRCA2 Protein Cell Line, Tumor Chromosome Segregation DNA Damage DNA Replication DNA-Binding Proteins Endonucleases HeLa Cells Humans Mitosis
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/179707
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1797072024-11-12T04:35:47Z MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells Lai, X Broderick, R Bergoglio, V Zimmer, J Badie, S Niedzwiedz, W Hoffmann, J.-S Tarsounas, M CANCER SCIENCE INSTITUTE OF SINGAPORE BRCA2 protein DNA endonuclease MUS81 endonuclease protein SLX4 scaffold protein small interfering RNA unclassified drug BRCA2 protein BRCA2 protein, human DNA DNA binding protein endonuclease MUS81 protein, human cells and cell components chromosome DNA environmental stress enzyme activity gene genome lesion tolerance anaphase Article cell stress cell survival chromosome chromosome segregation controlled study cytokinesis DNA damage DNA replication DNA synthesis enzyme activity enzyme inhibition female G1 phase cell cycle checkpoint genetic transfection human human cell mitosis protein depletion protein expression protein protein interaction chromosome segregation DNA damage genetics HeLa cell line metabolism tumor cell line Anaphase BRCA2 Protein Cell Line, Tumor Chromosome Segregation DNA DNA Damage DNA Replication DNA-Binding Proteins Endonucleases HeLa Cells Humans Mitosis 10.1038/ncomms15983 Nature Communications 8 15983 2020-10-26T02:44:32Z 2020-10-26T02:44:32Z 2017 Article Lai, X, Broderick, R, Bergoglio, V, Zimmer, J, Badie, S, Niedzwiedz, W, Hoffmann, J.-S, Tarsounas, M (2017). MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells. Nature Communications 8 : 15983. ScholarBank@NUS Repository. https://doi.org/10.1038/ncomms15983 2041-1723 https://scholarbank.nus.edu.sg/handle/10635/179707 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Nature Publishing Group Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	BRCA2 protein DNA endonuclease MUS81 endonuclease protein SLX4 scaffold protein small interfering RNA unclassified drug BRCA2 protein BRCA2 protein, human DNA DNA binding protein endonuclease MUS81 protein, human cells and cell components chromosome DNA environmental stress enzyme activity gene genome lesion tolerance anaphase Article cell stress cell survival chromosome chromosome segregation controlled study cytokinesis DNA damage DNA replication DNA synthesis enzyme activity enzyme inhibition female G1 phase cell cycle checkpoint genetic transfection human human cell mitosis protein depletion protein expression protein protein interaction chromosome segregation DNA damage genetics HeLa cell line metabolism tumor cell line Anaphase BRCA2 Protein Cell Line, Tumor Chromosome Segregation DNA DNA Damage DNA Replication DNA-Binding Proteins Endonucleases HeLa Cells Humans Mitosis
spellingShingle	BRCA2 protein DNA endonuclease MUS81 endonuclease protein SLX4 scaffold protein small interfering RNA unclassified drug BRCA2 protein BRCA2 protein, human DNA DNA binding protein endonuclease MUS81 protein, human cells and cell components chromosome DNA environmental stress enzyme activity gene genome lesion tolerance anaphase Article cell stress cell survival chromosome chromosome segregation controlled study cytokinesis DNA damage DNA replication DNA synthesis enzyme activity enzyme inhibition female G1 phase cell cycle checkpoint genetic transfection human human cell mitosis protein depletion protein expression protein protein interaction chromosome segregation DNA damage genetics HeLa cell line metabolism tumor cell line Anaphase BRCA2 Protein Cell Line, Tumor Chromosome Segregation DNA DNA Damage DNA Replication DNA-Binding Proteins Endonucleases HeLa Cells Humans Mitosis Lai, X Broderick, R Bergoglio, V Zimmer, J Badie, S Niedzwiedz, W Hoffmann, J.-S Tarsounas, M MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells
description	10.1038/ncomms15983
author2	CANCER SCIENCE INSTITUTE OF SINGAPORE
author_facet	CANCER SCIENCE INSTITUTE OF SINGAPORE Lai, X Broderick, R Bergoglio, V Zimmer, J Badie, S Niedzwiedz, W Hoffmann, J.-S Tarsounas, M
format	Article
author	Lai, X Broderick, R Bergoglio, V Zimmer, J Badie, S Niedzwiedz, W Hoffmann, J.-S Tarsounas, M
author_sort	Lai, X
title	MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells
title_short	MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells
title_full	MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells
title_fullStr	MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells
title_full_unstemmed	MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells
title_sort	mus81 nuclease activity is essential for replication stress tolerance and chromosome segregation in brca2-deficient cells
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/179707
_version_	1821187558327975936

MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells

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