Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information

• Main Authors: Horejs, C.-M, St-Pierre, J.-P, Ojala, J.R.M, Steele, J.A.M, Da Silva, P.B, Rynne-Vidal, A, Maynard, S.A, Hansel, C.S, Rodríguez-Fernández, C, Mazo, M.M, You, A.Y.F, Wang, A.J, Von Erlach, T, Tryggvason, K, López-Cabrera, M, Stevens, M.M
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: Acta2 protein; alpha3 integrin; beta1 integrin; biomaterial; cadherin; cadherin 2; cell protein; Col1a1 protein; Fn1 protein; gelatinase A; gelatinase B; laminin 1; laminin 1 beta; transcription factor Slug; transcription factor Snail; transforming growth factor beta1; unclassified drug; laminin; protein binding; very late activation antigen 3; anatomy; cells and cell components; gene; gene expression; hormone; protein; rodent; animal cell; animal experiment; animal model; animal tissue; Article; basement membrane; confocal microscopy; controlled study; drug delivery system; electrospinning; enzyme inhibition; epithelial mesenchymal transition; ex vivo study; extracellular matrix; female; fluorescence microscopy; HEK293 cell line; human; human cell; in vivo study; incubation time; male; mesothelium; mouse; nanofabrication; nonhuman; peritoneal fibrosis; protein content; protein function; protein protein interaction; Raman spectrometry; signal transduction; tissue structure; total internal reflection fluorescence microscopy; upregulation; animal; artificial membrane; chemistry; cytology; disease model; epithelium; epithelium cell; gene expression profiling; genetics; mammary gland; metabolism; pathology; peritoneum; Animals; Biocompatible Materials; Disease Models, Animal; Epithelial Cells; Epithelial-Mesenchymal Transition; Epithelium; Extracellular Matrix; Gene Expression Profiling; HEK293 Cells; Humans; Integrin alpha3beta1; Laminin; Mammary Glands, Human; Matrix Metalloproteinase 2; Membranes, Artificial; Mice; Peritoneal Fibrosis; Peritoneum; Protein Binding; Signal Transduction
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179712
• Institution: National University of Singapore

10.1038/ncomms15509