The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma
10.1038/ncomms14565
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2020
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sg-nus-scholar.10635-1797332024-11-15T09:01:38Z The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma Zhai, W Lim, T.K.-H Zhang, T Phang, S.-T Tiang, Z Guan, P Ng, M.-H Lim, J.Q Yao, F Li, Z Ng, P.Y Yan, J Goh, B.K Chung, A.Y.-F Choo, S.-P Khor, C.C Soon, W.W.-J Sung, K.W.-K Foo, R.S.-Y Chow, P.K.-H MEDICINE DEPARTMENT OF COMPUTER SCIENCE PHYSICS DUKE-NUS MEDICAL SCHOOL BIOCHEMISTRY cancer etiology genetic variation heterogeneity homeostasis mutation tumor Article controlled study copy number variation disease course drug repositioning gene mutation genetic variability human human tissue liver cell carcinoma liver metastasis metastasis phenotype phylogeny primary tumor biopsy DNA sequence genetics human genome liver liver cell carcinoma liver tumor metastasis mutation pathology virology virus DNA cell DNA interaction Biopsy Carcinoma, Hepatocellular DNA Copy Number Variations Genome, Human Humans Liver Liver Neoplasms Mutation Neoplasm Metastasis Phenotype Phylogeny Sequence Analysis, DNA Virus Integration 10.1038/ncomms14565 Nature Communications 8 4565 2020-10-26T02:49:57Z 2020-10-26T02:49:57Z 2017 Article Zhai, W, Lim, T.K.-H, Zhang, T, Phang, S.-T, Tiang, Z, Guan, P, Ng, M.-H, Lim, J.Q, Yao, F, Li, Z, Ng, P.Y, Yan, J, Goh, B.K, Chung, A.Y.-F, Choo, S.-P, Khor, C.C, Soon, W.W.-J, Sung, K.W.-K, Foo, R.S.-Y, Chow, P.K.-H (2017). The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma. Nature Communications 8 : 4565. ScholarBank@NUS Repository. https://doi.org/10.1038/ncomms14565 2041-1723 https://scholarbank.nus.edu.sg/handle/10635/179733 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Nature Publishing Group Unpaywall 20201031 |
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cancer etiology genetic variation heterogeneity homeostasis mutation tumor Article controlled study copy number variation disease course drug repositioning gene mutation genetic variability human human tissue liver cell carcinoma liver metastasis metastasis phenotype phylogeny primary tumor biopsy DNA sequence genetics human genome liver liver cell carcinoma liver tumor metastasis mutation pathology virology virus DNA cell DNA interaction Biopsy Carcinoma, Hepatocellular DNA Copy Number Variations Genome, Human Humans Liver Liver Neoplasms Mutation Neoplasm Metastasis Phenotype Phylogeny Sequence Analysis, DNA Virus Integration |
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cancer etiology genetic variation heterogeneity homeostasis mutation tumor Article controlled study copy number variation disease course drug repositioning gene mutation genetic variability human human tissue liver cell carcinoma liver metastasis metastasis phenotype phylogeny primary tumor biopsy DNA sequence genetics human genome liver liver cell carcinoma liver tumor metastasis mutation pathology virology virus DNA cell DNA interaction Biopsy Carcinoma, Hepatocellular DNA Copy Number Variations Genome, Human Humans Liver Liver Neoplasms Mutation Neoplasm Metastasis Phenotype Phylogeny Sequence Analysis, DNA Virus Integration Zhai, W Lim, T.K.-H Zhang, T Phang, S.-T Tiang, Z Guan, P Ng, M.-H Lim, J.Q Yao, F Li, Z Ng, P.Y Yan, J Goh, B.K Chung, A.Y.-F Choo, S.-P Khor, C.C Soon, W.W.-J Sung, K.W.-K Foo, R.S.-Y Chow, P.K.-H The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma |
| description |
10.1038/ncomms14565 |
| author2 |
MEDICINE |
| author_facet |
MEDICINE Zhai, W Lim, T.K.-H Zhang, T Phang, S.-T Tiang, Z Guan, P Ng, M.-H Lim, J.Q Yao, F Li, Z Ng, P.Y Yan, J Goh, B.K Chung, A.Y.-F Choo, S.-P Khor, C.C Soon, W.W.-J Sung, K.W.-K Foo, R.S.-Y Chow, P.K.-H |
| format |
Article |
| author |
Zhai, W Lim, T.K.-H Zhang, T Phang, S.-T Tiang, Z Guan, P Ng, M.-H Lim, J.Q Yao, F Li, Z Ng, P.Y Yan, J Goh, B.K Chung, A.Y.-F Choo, S.-P Khor, C.C Soon, W.W.-J Sung, K.W.-K Foo, R.S.-Y Chow, P.K.-H |
| author_sort |
Zhai, W |
| title |
The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma |
| title_short |
The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma |
| title_full |
The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma |
| title_fullStr |
The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma |
| title_full_unstemmed |
The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma |
| title_sort |
spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma |
| publisher |
Nature Publishing Group |
| publishDate |
2020 |
| url |
https://scholarbank.nus.edu.sg/handle/10635/179733 |
| _version_ |
1821229606622986240 |