The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma

• Main Authors: Zhai, W, Lim, T.K.-H, Zhang, T, Phang, S.-T, Tiang, Z, Guan, P, Ng, M.-H, Lim, J.Q, Yao, F, Li, Z, Ng, P.Y, Yan, J, Goh, B.K, Chung, A.Y.-F, Choo, S.-P, Khor, C.C, Soon, W.W.-J, Sung, K.W.-K, Foo, R.S.-Y, Chow, P.K.-H
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: cancer; etiology; genetic variation; heterogeneity; homeostasis; mutation; tumor; Article; controlled study; copy number variation; disease course; drug repositioning; gene mutation; genetic variability; human; human tissue; liver cell carcinoma; liver metastasis; metastasis; phenotype; phylogeny; primary tumor; biopsy; DNA sequence; genetics; human genome; liver; liver tumor; pathology; virology; virus DNA cell DNA interaction; Biopsy; Carcinoma, Hepatocellular; DNA Copy Number Variations; Genome, Human; Humans; Liver; Liver Neoplasms; Mutation; Neoplasm Metastasis; Phenotype; Phylogeny; Sequence Analysis, DNA; Virus Integration
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179733
• Institution: National University of Singapore

10.1038/ncomms14565