Targeted genomic analysis reveals widespread autoimmune disease association with regulatory variants in the TNF superfamily cytokine signalling network

• Main Authors: Richard, A.C, Peters, J.E, Lee, J.C, Vahedi, G, Schäffer, A.A, Siegel, R.M, Lyons, P.A, Smith, K.G.C
• Other Authors: MEDICINE
• Format: Article
• Published: 2020
• Subjects: tumor necrosis factor; tumor necrosis factor receptor; chromatin; isoprotein; Article; autoimmune disease; autoinflammatory disease; CD4+ T lymphocyte; CD8+ T lymphocyte; controlled study; enhancer region; gene expression; genetic marker; genetic variability; genome-wide association study; genomics; human; human cell; leukocyte; monocyte; neutrophil; priority journal; quantitative trait locus; single nucleotide polymorphism; allele; Autoimmune Diseases; chemistry; gene expression regulation; gene regulatory network; genetic predisposition; genetics; Hereditary Autoinflammatory Diseases; human genome; immunology; mononuclear cell; pathology; risk; signal transduction; Alleles; Chromatin; Gene Expression Regulation; Gene Regulatory Networks; Genetic Predisposition to Disease; Genome, Human; Genome-Wide Association Study; Humans; Leukocytes, Mononuclear; Protein Isoforms; Quantitative Trait Loci; Receptors, Tumor Necrosis Factor; Risk; Signal Transduction; Tumor Necrosis Factor-alpha
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179921
• Institution: National University of Singapore

10.1186/s13073-016-0329-5