Avoiding drug resistance through extended drug target interfaces: A case for stapled peptides

• المؤلفون الرئيسيون: Wei, S.J, Chee, S, Yurlova, L, Lane, D, Verma, C, Brown, C, Ghadessy, F
• مؤلفون آخرون: BIOLOGY
• التنسيق: مقال
• منشور في: 2020
• الموضوعات: nutlin; peptide inhibitor; protein inhibitor; protein MDM2; protein p53; unclassified drug; antineoplastic agent; MDM2 protein, human; peptide; protein binding; TP53 protein, human; animal cell; Article; BHK cell line; binding affinity; controlled study; drug protein binding; drug resistance; fibroblast; fluorescence polarization; immunoprecipitation; in vitro study; molecular model; mouse; neoplasm; nonhuman; phenotype; point mutation; protein expression; protein function; protein purification; Western blotting; wild type; animal; antagonists and inhibitors; binding site; cell line; chemistry; drug design; drug effects; gene expression regulation; genetics; genotype; human; metabolism; molecular mimicry; pathology; signal transduction; structure activity relation; Animals; Antineoplastic Agents; Binding Sites; Cell Line; Drug Design; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Genotype; Humans; Mice; Models, Molecular; Molecular Mimicry; Neoplasms; Peptides; Phenotype; Point Mutation; Protein Binding; Proto-Oncogene Proteins c-mdm2; Signal Transduction; Structure-Activity Relationship; Tumor Suppressor Protein p53
• الوصول للمادة أونلاين: https://scholarbank.nus.edu.sg/handle/10635/179927

10.18632/oncotarget.8572