Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis

10.1002/cmdc.201500414

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Bibliographic Details
Main Authors:	Hung, A.W, Silvestre, H.L, Wen, S, George, G.P.C, Boland, J, Blundell, T.L, Ciulli, A, Abell, C
Other Authors:	DEPT OF CHEMISTRY
Format:	Article
Published:	2020
Subjects:	antimycobacterial agent bacterial enzyme enzyme inhibitor functional group pantothenate synthetase pantothenate synthetase inhibitor unclassified drug peptide synthase tuberculostatic agent Article binding affinity crystal structure drug binding site drug design drug potency drug protein binding drug screening drug structure fragment based screening group efficiency analysis isothermal titration calorimetry ligand binding Mycobacterium tuberculosis nonhuman priority journal substitution reaction X ray crystallography antagonists and inhibitors chemical structure chemistry dose response drug development enzymology metabolism molecular model procedures structure activity relation synthesis Antitubercular Agents Crystallography, X-Ray Dose-Response Relationship, Drug Drug Discovery Enzyme Inhibitors Models, Molecular Molecular Structure Peptide Synthases Structure-Activity Relationship
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/179944
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Institution:	National University of Singapore

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