Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis

10.1002/cmdc.201500414

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Main Authors:	Hung, A.W, Silvestre, H.L, Wen, S, George, G.P.C, Boland, J, Blundell, T.L, Ciulli, A, Abell, C
Other Authors:	DEPT OF CHEMISTRY
Format:	Article
Published:	2020
Subjects:	antimycobacterial agent bacterial enzyme enzyme inhibitor functional group pantothenate synthetase pantothenate synthetase inhibitor unclassified drug peptide synthase tuberculostatic agent Article binding affinity crystal structure drug binding site drug design drug potency drug protein binding drug screening drug structure fragment based screening group efficiency analysis isothermal titration calorimetry ligand binding Mycobacterium tuberculosis nonhuman priority journal substitution reaction X ray crystallography antagonists and inhibitors chemical structure chemistry dose response drug development enzymology metabolism molecular model procedures structure activity relation synthesis Antitubercular Agents Crystallography, X-Ray Dose-Response Relationship, Drug Drug Discovery Enzyme Inhibitors Models, Molecular Molecular Structure Peptide Synthases Structure-Activity Relationship
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/179944
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1799442023-10-31T21:52:37Z Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis Hung, A.W Silvestre, H.L Wen, S George, G.P.C Boland, J Blundell, T.L Ciulli, A Abell, C DEPT OF CHEMISTRY antimycobacterial agent bacterial enzyme enzyme inhibitor functional group pantothenate synthetase pantothenate synthetase inhibitor unclassified drug enzyme inhibitor pantothenate synthetase peptide synthase tuberculostatic agent Article binding affinity crystal structure drug binding site drug design drug potency drug protein binding drug screening drug structure fragment based screening group efficiency analysis isothermal titration calorimetry ligand binding Mycobacterium tuberculosis nonhuman priority journal substitution reaction X ray crystallography antagonists and inhibitors chemical structure chemistry dose response drug development enzymology metabolism molecular model Mycobacterium tuberculosis procedures structure activity relation synthesis Antitubercular Agents Crystallography, X-Ray Dose-Response Relationship, Drug Drug Discovery Enzyme Inhibitors Models, Molecular Molecular Structure Mycobacterium tuberculosis Peptide Synthases Structure-Activity Relationship 10.1002/cmdc.201500414 ChemMedChem 11 1 38-42 2020-10-26T05:12:49Z 2020-10-26T05:12:49Z 2016 Article Hung, A.W, Silvestre, H.L, Wen, S, George, G.P.C, Boland, J, Blundell, T.L, Ciulli, A, Abell, C (2016). Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis. ChemMedChem 11 (1) : 38-42. ScholarBank@NUS Repository. https://doi.org/10.1002/cmdc.201500414 18607179 https://scholarbank.nus.edu.sg/handle/10635/179944 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	antimycobacterial agent bacterial enzyme enzyme inhibitor functional group pantothenate synthetase pantothenate synthetase inhibitor unclassified drug enzyme inhibitor pantothenate synthetase peptide synthase tuberculostatic agent Article binding affinity crystal structure drug binding site drug design drug potency drug protein binding drug screening drug structure fragment based screening group efficiency analysis isothermal titration calorimetry ligand binding Mycobacterium tuberculosis nonhuman priority journal substitution reaction X ray crystallography antagonists and inhibitors chemical structure chemistry dose response drug development enzymology metabolism molecular model Mycobacterium tuberculosis procedures structure activity relation synthesis Antitubercular Agents Crystallography, X-Ray Dose-Response Relationship, Drug Drug Discovery Enzyme Inhibitors Models, Molecular Molecular Structure Mycobacterium tuberculosis Peptide Synthases Structure-Activity Relationship
spellingShingle	antimycobacterial agent bacterial enzyme enzyme inhibitor functional group pantothenate synthetase pantothenate synthetase inhibitor unclassified drug enzyme inhibitor pantothenate synthetase peptide synthase tuberculostatic agent Article binding affinity crystal structure drug binding site drug design drug potency drug protein binding drug screening drug structure fragment based screening group efficiency analysis isothermal titration calorimetry ligand binding Mycobacterium tuberculosis nonhuman priority journal substitution reaction X ray crystallography antagonists and inhibitors chemical structure chemistry dose response drug development enzymology metabolism molecular model Mycobacterium tuberculosis procedures structure activity relation synthesis Antitubercular Agents Crystallography, X-Ray Dose-Response Relationship, Drug Drug Discovery Enzyme Inhibitors Models, Molecular Molecular Structure Mycobacterium tuberculosis Peptide Synthases Structure-Activity Relationship Hung, A.W Silvestre, H.L Wen, S George, G.P.C Boland, J Blundell, T.L Ciulli, A Abell, C Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis
description	10.1002/cmdc.201500414
author2	DEPT OF CHEMISTRY
author_facet	DEPT OF CHEMISTRY Hung, A.W Silvestre, H.L Wen, S George, G.P.C Boland, J Blundell, T.L Ciulli, A Abell, C
format	Article
author	Hung, A.W Silvestre, H.L Wen, S George, G.P.C Boland, J Blundell, T.L Ciulli, A Abell, C
author_sort	Hung, A.W
title	Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis
title_short	Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis
title_full	Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis
title_fullStr	Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis
title_full_unstemmed	Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis
title_sort	optimization of inhibitors of mycobacterium tuberculosis pantothenate synthetase based on group efficiency analysis
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/179944
_version_	1781792352935870464

Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis

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