Integrin α2β1 inhibits MST1 kinase phosphorylation and activates Yes-associated protein oncogenic signaling in hepatocellular carcinoma

• Main Authors: Wong, K.-F, Liu, A.M, Hong, W, Xu, Z, Luk, J.M
• Other Authors: INSTITUTE OF MOLECULAR & CELL BIOLOGY
• Format: Article
• Published: 2020
• Subjects: AXL receptor tyrosine kinase; cell protein; collagen; connective tissue growth factor; cyclin D1; glypican 3; large tumor suppressor homolog 1; mammalian sterile 20 like kinase 1; phosphotransferase; protein tyrosine kinase; somatomedin C receptor; SRY box 4; transcription factor Sox; transcription factor Yap1; unclassified drug; very late activation antigen 2; alpha2 integrin; beta1 integrin; CTGF protein, human; LATS1 protein, human; mammalian sterile 20-like kinase 1, human; phosphoprotein; protein serine threonine kinase; serine; signal transducing adaptor protein; YAP1 (Yes-associated) protein, human; adult; Article; cancer survival; carcinogenicity; cell adhesion; controlled study; CTGF gene; enzyme assay; enzyme phosphorylation; extracellular matrix; female; gene expression; gene silencing; genetic association; Hippo signaling pathway; human; human cell; human tissue; in vitro study; ITGA2 gene; liver cell carcinoma; male; oncogenic signaling; protein binding; protein expression; protein function; protein targeting; signal transduction; tumor growth; genetics; liver tumor; metabolism; phosphorylation; tumor cell line; Adaptor Proteins, Signal Transducing; Carcinoma, Hepatocellular; Cell Adhesion; Cell Line, Tumor; Connective Tissue Growth Factor; Female; Humans; Integrin alpha2; Integrin beta1; Liver Neoplasms; Male; Phosphoproteins; Phosphorylation; Protein-Serine-Threonine Kinases; Serine; Signal Transduction
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179958
• Institution: National University of Singapore

10.18632/oncotarget.12760