Genes from a translational analysis support a multifactorial nature of white matter hyperintensities

• Main Authors: Lopez, L.M, Hill, W.D, Harris, S.E, Valdes Hernandez, M, Munoz Maniega, S, Bastin, M.E, Bailey, E, Smith, C, McBride, M, McClure, J, Graham, D, Dominiczak, A, Yang, Q, Fornage, M, Ikram, M.A, Debette, S, Launer, L, Bis, J.C, Schmidt, R, Seshadri, S, Porteous, D.J, Starr, J, Deary, I.J, Wardlaw, J.M
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Lippincott Williams and Wilkins 2020
• Subjects: nuclear receptor NR4A3; afp gene; alb gene; Article; brain size; chromosome 1; chromosome 10; chromosome 13; chromosome 17; farp1 gene; gene; gene expression; genetic association; gnai1 gene; human; inpp5d gene; major clinical study; mrpl18 gene; nonhuman; priority journal; rat; rbm8a gene; single nucleotide polymorphism; sipa1l2 gene; stroke prone spontaneously hypertensive rat; white matter; white matter hyperintensity; xpnpep1 gene; aged; Alzheimer disease; animal; brain; causality; dementia; female; genetics; genome-wide association study; Leukoencephalopathies; male; pathology; procedures; risk factor; spontaneously hypertensive rat; translational research; Wistar rat; Aged; Alzheimer Disease; Animals; Brain; Causality; Dementia; Female; Genome-Wide Association Study; Humans; Male; Polymorphism, Single Nucleotide; Rats; Rats, Inbred SHR; Rats, Wistar; Risk Factors; Translational Medical Research; White Matter
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/180128
• Institution: National University of Singapore

10.1161/STROKEAHA.114.007649