KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro

• Main Authors: Zeeman, A.-M, Van Amsterdam, S.M, McNamara, C.W, Voorberg-van Der Wel, A, Klooster, E.J, Van Den Berg, A, Remarque, E.J, Plouffe, D.M, Van Gemert, G.-J, Luty, A, Sauerwein, R, Gagaring, K, Borboa, R, Chen, Z, Kuhen, K, Glynne, R.J, Chatterjee, A.K, Nagle, A, Roland, J, Winzeler, E.A, Leroy, D, Campo, B, Diagana, T.T, Yeung, B.K.S, Thomas, A.W, Kocken, C.H.M
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: 2020
• Subjects: amodiaquine; antibody; antimalarial agent; artesunate; atovaquone; benflumetol; bulaquine; chloroquine; cycloheximide; dihydroartemisinin; doxycycline; heat shock protein 70; kae 609; kaf 156; kai 407; mefloquine; npc 1161b; piperaquine; primaquine; proguanil; tafenoquine; unclassified drug; animal cell; animal experiment; animal model; antimalarial activity; antimalarial drug susceptibility; article; body weight; controlled study; dilution; drug efficacy; drug potency; drug structure; female; high throughput screening; hypnozoite; IC 50; in vitro study; infection prevention; liver cell; low drug dose; mouse; nonhuman; parasite development; parasitemia; plasmodium (life cycle stage); Plasmodium berghei infection; Plasmodium cynomolgi; Plasmodium vivax; priority journal; rhesus monkey; schizont; sporozoite; Animals; Antimalarials; Drug Evaluation, Preclinical; Female; Hepatocytes; Imidazoles; Liver; Macaca mulatta; Malaria; Mice; Mice, Inbred ICR; Pyrazines; Sporozoites
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/180146
• Institution: National University of Singapore

10.1128/AAC.01927-13