A preclinical evaluation of a novel multikinase inhibitor, SKLB-329, as a therapeutic agent against hepatocellular carcinoma

10.1002/ijc.28944

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Main Authors:	Zhong, L, Fu, X.-Y, Zou, C, Yang, L.-L, Zhou, S, Yang, J, Tang, Y, Cheng, C, Li, L.-L, Xiang, R, Chen, L.-J, Chen, Y.-Z, Wei, Y.-Q, Yang, S.-Y
Other Authors:	PHARMACY
Format:	Article
Published:	Wiley-Liss Inc. 2020
Subjects:	1-(4-((1H-pyrazolo(3,4-d)pyrimidin-4-yl)oxy)-2-fluorophenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea angiogenesis inhibitor antineoplastic agent carbanilamide derivative nicotinamide protein kinase inhibitor pyrazole derivative sorafenib analogs and derivatives animal Bagg albino mouse cancer transplantation Carcinoma, Hepatocellular cell motion cell proliferation cell survival chemistry cytology drug screening endothelium cell female human IC50 liver Liver Neoplasms metabolism mouse neovascularization (pathology) signal transduction tumor cell line umbilical vein endothelial cell zebra fish Angiogenesis Inhibitors Animals Antineoplastic Agents Cell Line, Tumor Cell Movement Cell Proliferation Cell Survival Drug Evaluation, Preclinical Endothelial Cells Female Human Umbilical Vein Endothelial Cells Humans Inhibitory Concentration 50 Liver Mice Mice, Inbred BALB C Neoplasm Transplantation Neovascularization, Pathologic Niacinamide Phenylurea Compounds Protein Kinase Inhibitors Pyrazoles Signal Transduction Zebrafish
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/180162
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1801622024-11-08T21:52:25Z A preclinical evaluation of a novel multikinase inhibitor, SKLB-329, as a therapeutic agent against hepatocellular carcinoma Zhong, L Fu, X.-Y Zou, C Yang, L.-L Zhou, S Yang, J Tang, Y Cheng, C Li, L.-L Xiang, R Chen, L.-J Chen, Y.-Z Wei, Y.-Q Yang, S.-Y PHARMACY 1-(4-((1H-pyrazolo(3,4-d)pyrimidin-4-yl)oxy)-2-fluorophenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea angiogenesis inhibitor antineoplastic agent carbanilamide derivative nicotinamide protein kinase inhibitor pyrazole derivative sorafenib analogs and derivatives animal Bagg albino mouse cancer transplantation Carcinoma, Hepatocellular cell motion cell proliferation cell survival chemistry cytology drug screening endothelium cell female human IC50 liver Liver Neoplasms metabolism mouse neovascularization (pathology) signal transduction tumor cell line umbilical vein endothelial cell zebra fish Angiogenesis Inhibitors Animals Antineoplastic Agents Carcinoma, Hepatocellular Cell Line, Tumor Cell Movement Cell Proliferation Cell Survival Drug Evaluation, Preclinical Endothelial Cells Female Human Umbilical Vein Endothelial Cells Humans Inhibitory Concentration 50 Liver Liver Neoplasms Mice Mice, Inbred BALB C Neoplasm Transplantation Neovascularization, Pathologic Niacinamide Phenylurea Compounds Protein Kinase Inhibitors Pyrazoles Signal Transduction Zebrafish 10.1002/ijc.28944 International Journal of Cancer 135 12 2972-2982 2020-10-26T07:17:55Z 2020-10-26T07:17:55Z 2014 Article Zhong, L, Fu, X.-Y, Zou, C, Yang, L.-L, Zhou, S, Yang, J, Tang, Y, Cheng, C, Li, L.-L, Xiang, R, Chen, L.-J, Chen, Y.-Z, Wei, Y.-Q, Yang, S.-Y (2014). A preclinical evaluation of a novel multikinase inhibitor, SKLB-329, as a therapeutic agent against hepatocellular carcinoma. International Journal of Cancer 135 (12) : 2972-2982. ScholarBank@NUS Repository. https://doi.org/10.1002/ijc.28944 0020-7136 https://scholarbank.nus.edu.sg/handle/10635/180162 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Wiley-Liss Inc. Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	1-(4-((1H-pyrazolo(3,4-d)pyrimidin-4-yl)oxy)-2-fluorophenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea angiogenesis inhibitor antineoplastic agent carbanilamide derivative nicotinamide protein kinase inhibitor pyrazole derivative sorafenib analogs and derivatives animal Bagg albino mouse cancer transplantation Carcinoma, Hepatocellular cell motion cell proliferation cell survival chemistry cytology drug screening endothelium cell female human IC50 liver Liver Neoplasms metabolism mouse neovascularization (pathology) signal transduction tumor cell line umbilical vein endothelial cell zebra fish Angiogenesis Inhibitors Animals Antineoplastic Agents Carcinoma, Hepatocellular Cell Line, Tumor Cell Movement Cell Proliferation Cell Survival Drug Evaluation, Preclinical Endothelial Cells Female Human Umbilical Vein Endothelial Cells Humans Inhibitory Concentration 50 Liver Liver Neoplasms Mice Mice, Inbred BALB C Neoplasm Transplantation Neovascularization, Pathologic Niacinamide Phenylurea Compounds Protein Kinase Inhibitors Pyrazoles Signal Transduction Zebrafish
spellingShingle	1-(4-((1H-pyrazolo(3,4-d)pyrimidin-4-yl)oxy)-2-fluorophenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea angiogenesis inhibitor antineoplastic agent carbanilamide derivative nicotinamide protein kinase inhibitor pyrazole derivative sorafenib analogs and derivatives animal Bagg albino mouse cancer transplantation Carcinoma, Hepatocellular cell motion cell proliferation cell survival chemistry cytology drug screening endothelium cell female human IC50 liver Liver Neoplasms metabolism mouse neovascularization (pathology) signal transduction tumor cell line umbilical vein endothelial cell zebra fish Angiogenesis Inhibitors Animals Antineoplastic Agents Carcinoma, Hepatocellular Cell Line, Tumor Cell Movement Cell Proliferation Cell Survival Drug Evaluation, Preclinical Endothelial Cells Female Human Umbilical Vein Endothelial Cells Humans Inhibitory Concentration 50 Liver Liver Neoplasms Mice Mice, Inbred BALB C Neoplasm Transplantation Neovascularization, Pathologic Niacinamide Phenylurea Compounds Protein Kinase Inhibitors Pyrazoles Signal Transduction Zebrafish Zhong, L Fu, X.-Y Zou, C Yang, L.-L Zhou, S Yang, J Tang, Y Cheng, C Li, L.-L Xiang, R Chen, L.-J Chen, Y.-Z Wei, Y.-Q Yang, S.-Y A preclinical evaluation of a novel multikinase inhibitor, SKLB-329, as a therapeutic agent against hepatocellular carcinoma
description	10.1002/ijc.28944
author2	PHARMACY
author_facet	PHARMACY Zhong, L Fu, X.-Y Zou, C Yang, L.-L Zhou, S Yang, J Tang, Y Cheng, C Li, L.-L Xiang, R Chen, L.-J Chen, Y.-Z Wei, Y.-Q Yang, S.-Y
format	Article
author	Zhong, L Fu, X.-Y Zou, C Yang, L.-L Zhou, S Yang, J Tang, Y Cheng, C Li, L.-L Xiang, R Chen, L.-J Chen, Y.-Z Wei, Y.-Q Yang, S.-Y
author_sort	Zhong, L
title	A preclinical evaluation of a novel multikinase inhibitor, SKLB-329, as a therapeutic agent against hepatocellular carcinoma
title_short	A preclinical evaluation of a novel multikinase inhibitor, SKLB-329, as a therapeutic agent against hepatocellular carcinoma
title_full	A preclinical evaluation of a novel multikinase inhibitor, SKLB-329, as a therapeutic agent against hepatocellular carcinoma
title_fullStr	A preclinical evaluation of a novel multikinase inhibitor, SKLB-329, as a therapeutic agent against hepatocellular carcinoma
title_full_unstemmed	A preclinical evaluation of a novel multikinase inhibitor, SKLB-329, as a therapeutic agent against hepatocellular carcinoma
title_sort	preclinical evaluation of a novel multikinase inhibitor, sklb-329, as a therapeutic agent against hepatocellular carcinoma
publisher	Wiley-Liss Inc.
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/180162
_version_	1821201207821074432

A preclinical evaluation of a novel multikinase inhibitor, SKLB-329, as a therapeutic agent against hepatocellular carcinoma

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