DNA methylation array analysis identifies breast cancer associated RPTOR, MGRN1 and RAPSN hypomethylation in peripheral blood DNA

• Main Authors: Tang, Q, Holland-Letz, T, Slynko, A, Cuk, K, Marme, F, Schott, S, Heil, J, Qu, B, Golatta, M, Bewerunge-Hudler, M, Sutter, C, Surowy, H, Wappenschmidt, B, Schmutzler, R, Hoth, M, Bugert, P, Bartram, C.R, Sohn, C, Schneeweiss, A, Yang, R, Burwinkel, B
• Other Authors: GEOGRAPHY
• Format: Article
• Published: Impact Journals LLC 2020
• Subjects: adult; area under the curve; Article; breast cancer; case control study; cell specificity; cohort analysis; controlled study; CpG island; DNA methylation; epigenetics; female; gene; gene locus; genetic association; human; human cell; leukocyte; major clinical study; MGRN1 gene; RAPSN gene; receiver operating characteristic; RPTOR gene; sensitivity and specificity; validation study; aged; blood; breast tumor; comparative study; DNA microarray; gene expression profiling; genetic epigenesis; genetic predisposition; genetics; middle aged; odds ratio; pathology; predictive value; procedures; reproducibility; retrospective study; risk factor; statistical model; circulating tumor DNA; MGRN1 protein, human; muscle protein; peripheral membrane protein 43K; regulatory associated protein of mTOR; RPTOR protein, human; tumor marker; ubiquitin protein ligase; Adult; Aged; Area Under Curve; Biomarkers, Tumor; Breast Neoplasms; Circulating Tumor DNA; CpG Islands; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Profiling; Genetic Predisposition to Disease; Humans; Logistic Models; Middle Aged; Muscle Proteins; Odds Ratio; Oligonucleotide Array Sequence Analysis; Predictive Value of Tests; Regulatory-Associated Protein of mTOR; Reproducibility of Results; Retrospective Studies; Risk Factors; ROC Curve; Ubiquitin-Protein Ligases
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/180382
• Institution: National University of Singapore

10.18632/oncotarget.11640