Nuclear envelope-associated endosomes deliver surface proteins to the nucleus

• Main Authors: Chaumet, A, Wright, G.D, Seet, S.H, Tham, K.M, Gounko, N.V, Bard, F
• Other Authors: DEPT OF BIOCHEMISTRY
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: cell surface protein; early endosome antigen 1; epidermal growth factor receptor; histone H1; membrane protein; nuclear protein; protein disulfide isomerase; Pseudomonas exotoxin; SUN1 protein; SUN2 protein; translocon; tubulin; unclassified drug; bacterial toxin; exotoxin; microtubule associated protein; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; nuclear localization signal; SEC61A1 protein, human; signal peptide; SUN1 protein, human; SUN2 protein, human; toxA protein, Pseudomonas aeruginosa; virulence factor; bacterium; cell organelle; cells and cell components; mobility; protein; RNA; translocation; Article; cell fractionation; cell nucleus; cell nucleus membrane; cell surface; controlled study; cytolysis; cytosol; cytosolic fraction; electron microscopy; endosome; female; Golgi complex; HeLa cell line; human; human cell; immunoprecipitation; inner membrane; nuclear import; nuclear pore; outer membrane; protein binding; protein localization; protein transport; regulatory mechanism; RNA interference; Western blotting; confocal microscopy; endocytosis; endoplasmic reticulum; fluorescent antibody technique; gene silencing; genetics; metabolism; tumor cell line; Bacteria (microorganisms); ADP Ribose Transferases; Bacterial Toxins; Cell Line, Tumor; Cell Nucleus; Cytosol; Endocytosis; Endoplasmic Reticulum; Endosomes; Exotoxins; Fluorescent Antibody Technique; Gene Knockdown Techniques; Golgi Apparatus; HeLa Cells; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Microscopy, Confocal; Microscopy, Electron; Microtubule-Associated Proteins; Nuclear Envelope; Nuclear Localization Signals; Nuclear Proteins; Protein Transport; SEC Translocation Channels; Virulence Factors
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/180439
• Institution: National University of Singapore

10.1038/ncomms9218