Mammalian adaptation of influenza A(H7N9) virus is limited by a narrow genetic bottleneck

• Main Authors: Zaraket, H, Baranovich, T, Kaplan, B.S, Carter, R, Song, M.-S, Paulson, J.C, Rehg, J.E, Bahl, J, Crumpton, J.C, Seiler, J, Edmonson, M, Wu, G, Karlsson, E, Fabrizio, T, Zhu, H, Guan, Y, Husain, M, Schultz-Cherry, S, Krauss, S, McBride, R, Webster, R.G, Govorkova, E.A, Zhang, J, Russell, C.J, Webby, R.J
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: adaptation; avian influenza; disease transmission; enzyme activity; epidemic; fitness; mammal; mutation; population bottleneck; poultry; public health; risk assessment; virus; adult; amino acid substitution; animal cell; animal experiment; animal model; Article; chicken; controlled study; ferret; gene replication; genetic analysis; genetic variability; human; human cell; in vitro study; Influenza virus A H7N9; male; MDCK cell line; neutrophil chemotaxis; nonhuman; receptor binding; sequence analysis; virus infectivity; virus recombinant; virus shedding; virus transmission; virus virulence; young adult; animal; asymptomatic infection; Chlorocebus aethiops; dog; genetic variation; genetics; HEK293 cell line; influenza; Influenza A virus (H7N9); multiplex polymerase chain reaction; orthomyxovirus infection; pathogenicity; reverse transcription polymerase chain reaction; transmission; Vero cell line; virology; Aves; Gallus gallus; Influenza A virus; Mammalia; Mustela; Orthomyxoviridae; core protein; influenza virus polymerase basic protein 1; NA protein, influenza A virus; NP protein, Influenza A virus; RNA binding protein; sialidase; viral protein; virus RNA; Adaptation, Physiological; Animals; Asymptomatic Infections; Cercopithecus aethiops; Chickens; Dogs; Ferrets; Genetic Variation; HEK293 Cells; Humans; Influenza A Virus, H7N9 Subtype; Influenza in Birds; Influenza, Human; Madin Darby Canine Kidney Cells; Multiplex Polymerase Chain Reaction; Mutation; Neuraminidase; Orthomyxoviridae Infections; Reverse Transcriptase Polymerase Chain Reaction; RNA, Viral; RNA-Binding Proteins; Vero Cells; Viral Core Proteins; Viral Proteins
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/180476
• Institution: National University of Singapore

10.1038/ncomms7553