An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma

• Main Authors: Chakraborty, S, Lakshmanan, M, Swa, H.L.F, Chen, J, Zhang, X, Ong, Y.S, Loo, L.S, Aklncllar, S.C, Gunaratne, J, Tergaonkar, V, Hui, K.M, Hong, W
• Other Authors: ANATOMY
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: actin related protein 2-3 complex; agrin; cell surface protein; muscle specific tyrosine kinase; protein tyrosine kinase; small interfering RNA; unclassified drug; blocking antibody; cholinergic receptor; focal adhesion kinase; integrin; low density lipoprotein receptor related protein; LRP4 protein, human; MUSK protein, human; tumor protein; adhesion; amino acid; antibody; biochemistry; cancer; cells and cell components; enzyme activity; gene expression; proteomics; secretion; tumor; animal experiment; animal model; animal tissue; Article; breast carcinoma; carcinogenesis; cell invasion; cell migration; cell motility; cell proliferation; confocal microscopy; epithelial mesenchymal transition; extracellular matrix; female; focal adhesion; gene control; gene overexpression; gene silencing; human; human cell; human tissue; immunofluorescence; immunohistochemistry; in vivo study; lipid raft; liver cell carcinoma; mouse; nonhuman; oncogene; protein analysis; protein function; reverse transcription polymerase chain reaction; signal transduction; tumor growth; upregulation; Western blotting; animal; apoptosis; cell adhesion; cell membrane; cell motion; drug effects; drug screening; endocytosis; isotope labeling; liver tumor; metabolism; nude mouse; pathology; pseudopodium; tumor cell line; tumor invasion; tumor stem cell assay; Agrin; Animals; Antibodies, Blocking; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Endocytosis; Epithelial-Mesenchymal Transition; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Gene Knockdown Techniques; Integrins; Isotope Labeling; LDL-Receptor Related Proteins; Liver Neoplasms; Membrane Microdomains; Mice, Nude; Neoplasm Invasiveness; Neoplasm Proteins; Oncogenes; Pseudopodia; Receptor Protein-Tyrosine Kinases; Receptors, Cholinergic; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/180480
• Institution: National University of Singapore

10.1038/ncomms7184