An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma

10.1038/ncomms7184

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Main Authors:	Chakraborty, S, Lakshmanan, M, Swa, H.L.F, Chen, J, Zhang, X, Ong, Y.S, Loo, L.S, Aklncllar, S.C, Gunaratne, J, Tergaonkar, V, Hui, K.M, Hong, W
Other Authors:	ANATOMY
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	actin related protein 2-3 complex agrin cell surface protein muscle specific tyrosine kinase protein tyrosine kinase small interfering RNA unclassified drug blocking antibody cholinergic receptor focal adhesion kinase integrin low density lipoprotein receptor related protein LRP4 protein, human MUSK protein, human tumor protein adhesion amino acid antibody biochemistry cancer cells and cell components enzyme activity gene expression proteomics secretion tumor animal experiment animal model animal tissue Article breast carcinoma carcinogenesis cell invasion cell migration cell motility cell proliferation confocal microscopy epithelial mesenchymal transition extracellular matrix female focal adhesion gene control gene overexpression gene silencing human human cell human tissue immunofluorescence immunohistochemistry in vivo study lipid raft liver cell carcinoma mouse nonhuman oncogene protein analysis protein function reverse transcription polymerase chain reaction signal transduction tumor growth upregulation Western blotting animal apoptosis cell adhesion cell membrane cell motion drug effects drug screening endocytosis isotope labeling liver tumor metabolism nude mouse pathology pseudopodium tumor cell line tumor invasion tumor stem cell assay Agrin Animals Antibodies, Blocking Apoptosis Carcinogenesis Carcinoma, Hepatocellular Cell Adhesion Cell Line, Tumor Cell Movement Cell Proliferation Endocytosis Epithelial-Mesenchymal Transition Focal Adhesion Protein-Tyrosine Kinases Focal Adhesions Gene Knockdown Techniques Integrins Isotope Labeling LDL-Receptor Related Proteins Liver Neoplasms Membrane Microdomains Mice, Nude Neoplasm Invasiveness Neoplasm Proteins Oncogenes Pseudopodia Receptor Protein-Tyrosine Kinases Receptors, Cholinergic Tumor Stem Cell Assay Xenograft Model Antitumor Assays
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/180480
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1804802024-11-14T22:35:34Z An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma Chakraborty, S Lakshmanan, M Swa, H.L.F Chen, J Zhang, X Ong, Y.S Loo, L.S Aklncllar, S.C Gunaratne, J Tergaonkar, V Hui, K.M Hong, W ANATOMY INSTITUTE OF MOLECULAR & CELL BIOLOGY PATHOLOGY actin related protein 2-3 complex agrin cell surface protein muscle specific tyrosine kinase protein tyrosine kinase small interfering RNA unclassified drug agrin blocking antibody cholinergic receptor focal adhesion kinase integrin low density lipoprotein receptor related protein LRP4 protein, human MUSK protein, human protein tyrosine kinase tumor protein adhesion amino acid antibody biochemistry cancer cells and cell components enzyme activity gene expression proteomics secretion tumor animal experiment animal model animal tissue Article breast carcinoma carcinogenesis cell invasion cell migration cell motility cell proliferation confocal microscopy epithelial mesenchymal transition extracellular matrix female focal adhesion gene control gene overexpression gene silencing human human cell human tissue immunofluorescence immunohistochemistry in vivo study lipid raft liver cell carcinoma mouse nonhuman oncogene protein analysis protein function proteomics reverse transcription polymerase chain reaction signal transduction tumor growth upregulation Western blotting animal apoptosis cell adhesion cell membrane cell motion drug effects drug screening endocytosis focal adhesion isotope labeling liver cell carcinoma liver tumor metabolism nude mouse pathology pseudopodium tumor cell line tumor invasion tumor stem cell assay Agrin Animals Antibodies, Blocking Apoptosis Carcinogenesis Carcinoma, Hepatocellular Cell Adhesion Cell Line, Tumor Cell Movement Cell Proliferation Endocytosis Epithelial-Mesenchymal Transition Focal Adhesion Protein-Tyrosine Kinases Focal Adhesions Gene Knockdown Techniques Integrins Isotope Labeling LDL-Receptor Related Proteins Liver Neoplasms Membrane Microdomains Mice, Nude Neoplasm Invasiveness Neoplasm Proteins Oncogenes Pseudopodia Receptor Protein-Tyrosine Kinases Receptors, Cholinergic Tumor Stem Cell Assay Xenograft Model Antitumor Assays 10.1038/ncomms7184 Nature Communications 6 7184 2020-10-26T09:10:08Z 2020-10-26T09:10:08Z 2015 Article Chakraborty, S, Lakshmanan, M, Swa, H.L.F, Chen, J, Zhang, X, Ong, Y.S, Loo, L.S, Aklncllar, S.C, Gunaratne, J, Tergaonkar, V, Hui, K.M, Hong, W (2015). An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma. Nature Communications 6 : 7184. ScholarBank@NUS Repository. https://doi.org/10.1038/ncomms7184 2041-1723 https://scholarbank.nus.edu.sg/handle/10635/180480 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Nature Publishing Group Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	actin related protein 2-3 complex agrin cell surface protein muscle specific tyrosine kinase protein tyrosine kinase small interfering RNA unclassified drug agrin blocking antibody cholinergic receptor focal adhesion kinase integrin low density lipoprotein receptor related protein LRP4 protein, human MUSK protein, human protein tyrosine kinase tumor protein adhesion amino acid antibody biochemistry cancer cells and cell components enzyme activity gene expression proteomics secretion tumor animal experiment animal model animal tissue Article breast carcinoma carcinogenesis cell invasion cell migration cell motility cell proliferation confocal microscopy epithelial mesenchymal transition extracellular matrix female focal adhesion gene control gene overexpression gene silencing human human cell human tissue immunofluorescence immunohistochemistry in vivo study lipid raft liver cell carcinoma mouse nonhuman oncogene protein analysis protein function proteomics reverse transcription polymerase chain reaction signal transduction tumor growth upregulation Western blotting animal apoptosis cell adhesion cell membrane cell motion drug effects drug screening endocytosis focal adhesion isotope labeling liver cell carcinoma liver tumor metabolism nude mouse pathology pseudopodium tumor cell line tumor invasion tumor stem cell assay Agrin Animals Antibodies, Blocking Apoptosis Carcinogenesis Carcinoma, Hepatocellular Cell Adhesion Cell Line, Tumor Cell Movement Cell Proliferation Endocytosis Epithelial-Mesenchymal Transition Focal Adhesion Protein-Tyrosine Kinases Focal Adhesions Gene Knockdown Techniques Integrins Isotope Labeling LDL-Receptor Related Proteins Liver Neoplasms Membrane Microdomains Mice, Nude Neoplasm Invasiveness Neoplasm Proteins Oncogenes Pseudopodia Receptor Protein-Tyrosine Kinases Receptors, Cholinergic Tumor Stem Cell Assay Xenograft Model Antitumor Assays
spellingShingle	actin related protein 2-3 complex agrin cell surface protein muscle specific tyrosine kinase protein tyrosine kinase small interfering RNA unclassified drug agrin blocking antibody cholinergic receptor focal adhesion kinase integrin low density lipoprotein receptor related protein LRP4 protein, human MUSK protein, human protein tyrosine kinase tumor protein adhesion amino acid antibody biochemistry cancer cells and cell components enzyme activity gene expression proteomics secretion tumor animal experiment animal model animal tissue Article breast carcinoma carcinogenesis cell invasion cell migration cell motility cell proliferation confocal microscopy epithelial mesenchymal transition extracellular matrix female focal adhesion gene control gene overexpression gene silencing human human cell human tissue immunofluorescence immunohistochemistry in vivo study lipid raft liver cell carcinoma mouse nonhuman oncogene protein analysis protein function proteomics reverse transcription polymerase chain reaction signal transduction tumor growth upregulation Western blotting animal apoptosis cell adhesion cell membrane cell motion drug effects drug screening endocytosis focal adhesion isotope labeling liver cell carcinoma liver tumor metabolism nude mouse pathology pseudopodium tumor cell line tumor invasion tumor stem cell assay Agrin Animals Antibodies, Blocking Apoptosis Carcinogenesis Carcinoma, Hepatocellular Cell Adhesion Cell Line, Tumor Cell Movement Cell Proliferation Endocytosis Epithelial-Mesenchymal Transition Focal Adhesion Protein-Tyrosine Kinases Focal Adhesions Gene Knockdown Techniques Integrins Isotope Labeling LDL-Receptor Related Proteins Liver Neoplasms Membrane Microdomains Mice, Nude Neoplasm Invasiveness Neoplasm Proteins Oncogenes Pseudopodia Receptor Protein-Tyrosine Kinases Receptors, Cholinergic Tumor Stem Cell Assay Xenograft Model Antitumor Assays Chakraborty, S Lakshmanan, M Swa, H.L.F Chen, J Zhang, X Ong, Y.S Loo, L.S Aklncllar, S.C Gunaratne, J Tergaonkar, V Hui, K.M Hong, W An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma
description	10.1038/ncomms7184
author2	ANATOMY
author_facet	ANATOMY Chakraborty, S Lakshmanan, M Swa, H.L.F Chen, J Zhang, X Ong, Y.S Loo, L.S Aklncllar, S.C Gunaratne, J Tergaonkar, V Hui, K.M Hong, W
format	Article
author	Chakraborty, S Lakshmanan, M Swa, H.L.F Chen, J Zhang, X Ong, Y.S Loo, L.S Aklncllar, S.C Gunaratne, J Tergaonkar, V Hui, K.M Hong, W
author_sort	Chakraborty, S
title	An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma
title_short	An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma
title_full	An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma
title_fullStr	An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma
title_full_unstemmed	An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma
title_sort	oncogenic role of agrin in regulating focal adhesion integrity in hepatocellular carcinoma
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/180480
_version_	1821211417917784064

An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma

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