Tropomodulin3 is a novel Akt2 effector regulating insulin-stimulated GLUT4 exocytosis through cortical actin remodeling

• Main Authors: Lim, C.-Y, Bi, X, Wu, D, Kim, J.B, Gunning, P.W, Hong, W, Han, W
• Other Authors: INSTITUTE OF MOLECULAR & CELL BIOLOGY
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: actin binding protein; actin capping protein; F actin; G actin; glucose transporter 4; latrunculin B; protein kinase B beta; tropomodulin; tropomodulin 3; unclassified drug; actin; AKT2 protein, human; Akt2 protein, mouse; glucose; insulin; protein kinase B; SLC2A4 protein, human; Slc2a4 protein, mouse; TMOD3 protein, human; Tmod3 protein, mouse; cells and cell components; chemical reaction; membrane; numerical model; protein; translocation; actin filament; adipocyte; Article; cross linking; exocytosis; glucose transport; human; human cell; mass spectrometry; protein interaction; protein phosphorylation; proteomics; signal transduction; 3T3 cell line; animal; C57BL mouse; cell membrane; fluorescence microscopy; Lentivirinae; male; metabolism; mouse; phosphorylation; thrombocyte; 3T3-L1 Cells; Actins; Adipocytes; Animals; Blood Platelets; Cell Membrane; Exocytosis; Glucose; Glucose Transporter Type 4; Humans; Insulin; Lentivirus; Male; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Phosphorylation; Proto-Oncogene Proteins c-akt; Tropomodulin
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/180482
• Institution: National University of Singapore

10.1038/ncomms6951