Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition by way of Akt/GSK-3β/Snail signaling

• Main Authors: Liu, L, Dai, Y, Chen, J, Zeng, T, Li, Y, Chen, L, Zhu, Y.-H, Li, J, Ma, S, Xie, D, Yuan, Y.-F, Guan, X.-Y
• Other Authors: ANATOMY
• Format: Article
• Published: John Wiley and Sons Inc. 2020
• Subjects: activated leukocyte cell adhesion molecule; alpha catenin; beta catenin; BMI1 protein; CD133 antigen; CD24 antigen; cell surface marker; endoglin; fibronectin; glycogen synthase kinase 3beta; Hermes antigen; membrane antigen; messenger RNA; Notch1 receptor; octamer transcription factor 4; protein kinase B; short hairpin RNA; transcription factor NANOG; transcription factor Snail; uvomorulin; vimentin; adult; animal experiment; animal model; animal tissue; article; cancer recurrence; cancer resistance; cancer stem cell; cancer survival; carcinogenesis; carcinogenicity; cell growth; cell migration; cell motility; cell renewal; chemosensitivity; chromosome 1q; controlled study; enzyme activity; epithelial mesenchymal transition; female; gene amplification; gene overexpression; gene silencing; human; human cell; human tissue; liver cell carcinoma; Maelstrom gene; male; metastasis; middle aged; mouse; multidrug resistance; nonhuman; oncogene; overall survival; priority journal; RNA interference; signal transduction; tumor invasion; tumor volume; tumor xenograft; upregulation; Animals; Carcinoma, Hepatocellular; Carrier Proteins; Cell Movement; Cell Proliferation; Disease Models, Animal; Disease Progression; Epithelial-Mesenchymal Transition; Female; Glycogen Synthase Kinase 3; Humans; Liver Neoplasms; Male; Mice; Middle Aged; Neoplasm Metastasis; Proto-Oncogene Proteins c-akt; RNA, Messenger; Signal Transduction; Transcription Factors; Up-Regulation
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/180768
• Institution: National University of Singapore

10.1002/hep.26677