Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice

10.1074/jbc.M113.492017

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Main Authors:	Shelkovnikova, T.A, Peters, O.M, Deykin, A.V, Connor-Robson, N, Robinson, H, Ustyugov, A.A, Bachurin, S.O, Ermolkevich, T.G, Goldman, I.L, Sadchikova, E.R, Kovrazhkina, E.A, Skvortsova, V.I, Ling, S.-C, Da Cruz, S, Parone, P.A, Buchman, V.L, Ninkina, N.N
Other Authors:	PHYSIOLOGY
Format:	Article
Published:	2020
Subjects:	Amyotrophic lateral sclerosis Fused in sarcomata Nuclear localization signal Protein aggregation RNA-binding motif Transgenic mice Mammals Neurodegenerative diseases Proteins fused in sarcoma protein amyotrophic lateral sclerosis animal cell animal experiment animal model animal tissue article clinical feature controlled study disease course disease severity lifespan mortality motoneuron motor dysfunction mouse nerve cell lesion nerve fiber nervous system inflammation nonhuman nuclear localization signal pathophysiology phenotype priority journal protein defect protein expression protein motif RNA binding transgenic mouse Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) Animal Models Motor Neuron Disease Neurodegeneration Protein Aggregation Proteinopathy RNA Metabolism RNA-binding Proteins TDP-43 Transgenic Mouse Amino Acid Motifs Amino Acid Sequence Amyotrophic Lateral Sclerosis Animals Axons Cytoplasm Humans Mice Mice, Transgenic Motor Neurons Nuclear Localization Signals Phenotype RNA RNA-Binding Protein FUS Sequence Deletion
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/180783
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1807832024-04-04T01:10:25Z Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice Shelkovnikova, T.A Peters, O.M Deykin, A.V Connor-Robson, N Robinson, H Ustyugov, A.A Bachurin, S.O Ermolkevich, T.G Goldman, I.L Sadchikova, E.R Kovrazhkina, E.A Skvortsova, V.I Ling, S.-C Da Cruz, S Parone, P.A Buchman, V.L Ninkina, N.N PHYSIOLOGY Amyotrophic lateral sclerosis Fused in sarcomata Nuclear localization signal Protein aggregation RNA-binding motif Transgenic mice Mammals Neurodegenerative diseases Proteins fused in sarcoma protein amyotrophic lateral sclerosis animal cell animal experiment animal model animal tissue article clinical feature controlled study disease course disease severity lifespan mortality motoneuron motor dysfunction mouse nerve cell lesion nerve fiber nervous system inflammation nonhuman nuclear localization signal pathophysiology phenotype priority journal protein defect protein expression protein motif RNA binding transgenic mouse Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) Animal Models Motor Neuron Disease Neurodegeneration Protein Aggregation Proteinopathy RNA Metabolism RNA-binding Proteins TDP-43 Transgenic Mouse Amino Acid Motifs Amino Acid Sequence Amyotrophic Lateral Sclerosis Animals Axons Cytoplasm Humans Mice Mice, Transgenic Motor Neurons Nuclear Localization Signals Phenotype RNA RNA-Binding Protein FUS Sequence Deletion 10.1074/jbc.M113.492017 Journal of Biological Chemistry 288 35 25266-25274 2020-10-27T04:44:21Z 2020-10-27T04:44:21Z 2013 Article Shelkovnikova, T.A, Peters, O.M, Deykin, A.V, Connor-Robson, N, Robinson, H, Ustyugov, A.A, Bachurin, S.O, Ermolkevich, T.G, Goldman, I.L, Sadchikova, E.R, Kovrazhkina, E.A, Skvortsova, V.I, Ling, S.-C, Da Cruz, S, Parone, P.A, Buchman, V.L, Ninkina, N.N (2013). Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice. Journal of Biological Chemistry 288 (35) : 25266-25274. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M113.492017 0021-9258 https://scholarbank.nus.edu.sg/handle/10635/180783 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	Amyotrophic lateral sclerosis Fused in sarcomata Nuclear localization signal Protein aggregation RNA-binding motif Transgenic mice Mammals Neurodegenerative diseases Proteins fused in sarcoma protein amyotrophic lateral sclerosis animal cell animal experiment animal model animal tissue article clinical feature controlled study disease course disease severity lifespan mortality motoneuron motor dysfunction mouse nerve cell lesion nerve fiber nervous system inflammation nonhuman nuclear localization signal pathophysiology phenotype priority journal protein defect protein expression protein motif RNA binding transgenic mouse Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) Animal Models Motor Neuron Disease Neurodegeneration Protein Aggregation Proteinopathy RNA Metabolism RNA-binding Proteins TDP-43 Transgenic Mouse Amino Acid Motifs Amino Acid Sequence Amyotrophic Lateral Sclerosis Animals Axons Cytoplasm Humans Mice Mice, Transgenic Motor Neurons Nuclear Localization Signals Phenotype RNA RNA-Binding Protein FUS Sequence Deletion
spellingShingle	Amyotrophic lateral sclerosis Fused in sarcomata Nuclear localization signal Protein aggregation RNA-binding motif Transgenic mice Mammals Neurodegenerative diseases Proteins fused in sarcoma protein amyotrophic lateral sclerosis animal cell animal experiment animal model animal tissue article clinical feature controlled study disease course disease severity lifespan mortality motoneuron motor dysfunction mouse nerve cell lesion nerve fiber nervous system inflammation nonhuman nuclear localization signal pathophysiology phenotype priority journal protein defect protein expression protein motif RNA binding transgenic mouse Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) Animal Models Motor Neuron Disease Neurodegeneration Protein Aggregation Proteinopathy RNA Metabolism RNA-binding Proteins TDP-43 Transgenic Mouse Amino Acid Motifs Amino Acid Sequence Amyotrophic Lateral Sclerosis Animals Axons Cytoplasm Humans Mice Mice, Transgenic Motor Neurons Nuclear Localization Signals Phenotype RNA RNA-Binding Protein FUS Sequence Deletion Shelkovnikova, T.A Peters, O.M Deykin, A.V Connor-Robson, N Robinson, H Ustyugov, A.A Bachurin, S.O Ermolkevich, T.G Goldman, I.L Sadchikova, E.R Kovrazhkina, E.A Skvortsova, V.I Ling, S.-C Da Cruz, S Parone, P.A Buchman, V.L Ninkina, N.N Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice
description	10.1074/jbc.M113.492017
author2	PHYSIOLOGY
author_facet	PHYSIOLOGY Shelkovnikova, T.A Peters, O.M Deykin, A.V Connor-Robson, N Robinson, H Ustyugov, A.A Bachurin, S.O Ermolkevich, T.G Goldman, I.L Sadchikova, E.R Kovrazhkina, E.A Skvortsova, V.I Ling, S.-C Da Cruz, S Parone, P.A Buchman, V.L Ninkina, N.N
format	Article
author	Shelkovnikova, T.A Peters, O.M Deykin, A.V Connor-Robson, N Robinson, H Ustyugov, A.A Bachurin, S.O Ermolkevich, T.G Goldman, I.L Sadchikova, E.R Kovrazhkina, E.A Skvortsova, V.I Ling, S.-C Da Cruz, S Parone, P.A Buchman, V.L Ninkina, N.N
author_sort	Shelkovnikova, T.A
title	Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice
title_short	Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice
title_full	Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice
title_fullStr	Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice
title_full_unstemmed	Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice
title_sort	fused in sarcoma (fus) protein lacking nuclear localization signal (nls) and major rna binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/180783
_version_	1795374524863086592

Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice

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