The investigational aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell-cycle progression in malignant bladder cancer cells in vitro and in vivo

10.1158/1078-0432.CCR-12-2383

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Main Authors:	Zhou, N, Singh, K, Mir, M.C, Parker, Y, Lindner, D, Dreicer, R, Ecsedy, J.A, Zhang, Z, Teh, B.T, Almasan, A, Hansel, D.E
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	2020
Subjects:	alisertib gemcitabine paclitaxel aneuploidy animal experiment animal model antineoplastic activity apoptosis article bladder papilloma cancer inhibition cell cycle arrest controlled study drug cytotoxicity drug potentiation gene expression regulation gene overexpression gene sequence human human cell in vitro study in vivo study microarray analysis mouse nonhuman priority journal reverse transcription polymerase chain reaction upregulation Aneuploidy Animals Apoptosis Azepines Cell Cycle Cell Cycle Checkpoints Cell Line, Tumor Cell Survival Cluster Analysis Deoxycytidine Drug Synergism Gene Expression Gene Expression Profiling Humans M Phase Cell Cycle Checkpoints Mice Neoplasm Invasiveness Paclitaxel Phenotype Protein-Serine-Threonine Kinases Pyrimidines Tumor Burden Urinary Bladder Neoplasms Xenograft Model Antitumor Assays
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/180801
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1808012023-08-29T09:55:50Z The investigational aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell-cycle progression in malignant bladder cancer cells in vitro and in vivo Zhou, N Singh, K Mir, M.C Parker, Y Lindner, D Dreicer, R Ecsedy, J.A Zhang, Z Teh, B.T Almasan, A Hansel, D.E DUKE-NUS MEDICAL SCHOOL alisertib gemcitabine paclitaxel aneuploidy animal experiment animal model antineoplastic activity apoptosis article bladder papilloma cancer inhibition cell cycle arrest controlled study drug cytotoxicity drug potentiation gene expression regulation gene overexpression gene sequence human human cell in vitro study in vivo study microarray analysis mouse nonhuman priority journal reverse transcription polymerase chain reaction upregulation Aneuploidy Animals Apoptosis Azepines Cell Cycle Cell Cycle Checkpoints Cell Line, Tumor Cell Survival Cluster Analysis Deoxycytidine Drug Synergism Gene Expression Gene Expression Profiling Humans M Phase Cell Cycle Checkpoints Mice Neoplasm Invasiveness Paclitaxel Phenotype Protein-Serine-Threonine Kinases Pyrimidines Tumor Burden Urinary Bladder Neoplasms Xenograft Model Antitumor Assays 10.1158/1078-0432.CCR-12-2383 Clinical Cancer Research 19 7 1717-1728 2020-10-27T04:47:47Z 2020-10-27T04:47:47Z 2013 Article Zhou, N, Singh, K, Mir, M.C, Parker, Y, Lindner, D, Dreicer, R, Ecsedy, J.A, Zhang, Z, Teh, B.T, Almasan, A, Hansel, D.E (2013). The investigational aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell-cycle progression in malignant bladder cancer cells in vitro and in vivo. Clinical Cancer Research 19 (7) : 1717-1728. ScholarBank@NUS Repository. https://doi.org/10.1158/1078-0432.CCR-12-2383 1078-0432 https://scholarbank.nus.edu.sg/handle/10635/180801 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	alisertib gemcitabine paclitaxel aneuploidy animal experiment animal model antineoplastic activity apoptosis article bladder papilloma cancer inhibition cell cycle arrest controlled study drug cytotoxicity drug potentiation gene expression regulation gene overexpression gene sequence human human cell in vitro study in vivo study microarray analysis mouse nonhuman priority journal reverse transcription polymerase chain reaction upregulation Aneuploidy Animals Apoptosis Azepines Cell Cycle Cell Cycle Checkpoints Cell Line, Tumor Cell Survival Cluster Analysis Deoxycytidine Drug Synergism Gene Expression Gene Expression Profiling Humans M Phase Cell Cycle Checkpoints Mice Neoplasm Invasiveness Paclitaxel Phenotype Protein-Serine-Threonine Kinases Pyrimidines Tumor Burden Urinary Bladder Neoplasms Xenograft Model Antitumor Assays
spellingShingle	alisertib gemcitabine paclitaxel aneuploidy animal experiment animal model antineoplastic activity apoptosis article bladder papilloma cancer inhibition cell cycle arrest controlled study drug cytotoxicity drug potentiation gene expression regulation gene overexpression gene sequence human human cell in vitro study in vivo study microarray analysis mouse nonhuman priority journal reverse transcription polymerase chain reaction upregulation Aneuploidy Animals Apoptosis Azepines Cell Cycle Cell Cycle Checkpoints Cell Line, Tumor Cell Survival Cluster Analysis Deoxycytidine Drug Synergism Gene Expression Gene Expression Profiling Humans M Phase Cell Cycle Checkpoints Mice Neoplasm Invasiveness Paclitaxel Phenotype Protein-Serine-Threonine Kinases Pyrimidines Tumor Burden Urinary Bladder Neoplasms Xenograft Model Antitumor Assays Zhou, N Singh, K Mir, M.C Parker, Y Lindner, D Dreicer, R Ecsedy, J.A Zhang, Z Teh, B.T Almasan, A Hansel, D.E The investigational aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell-cycle progression in malignant bladder cancer cells in vitro and in vivo
description	10.1158/1078-0432.CCR-12-2383
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Zhou, N Singh, K Mir, M.C Parker, Y Lindner, D Dreicer, R Ecsedy, J.A Zhang, Z Teh, B.T Almasan, A Hansel, D.E
format	Article
author	Zhou, N Singh, K Mir, M.C Parker, Y Lindner, D Dreicer, R Ecsedy, J.A Zhang, Z Teh, B.T Almasan, A Hansel, D.E
author_sort	Zhou, N
title	The investigational aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell-cycle progression in malignant bladder cancer cells in vitro and in vivo
title_short	The investigational aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell-cycle progression in malignant bladder cancer cells in vitro and in vivo
title_full	The investigational aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell-cycle progression in malignant bladder cancer cells in vitro and in vivo
title_fullStr	The investigational aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell-cycle progression in malignant bladder cancer cells in vitro and in vivo
title_full_unstemmed	The investigational aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell-cycle progression in malignant bladder cancer cells in vitro and in vivo
title_sort	investigational aurora kinase a inhibitor mln8237 induces defects in cell viability and cell-cycle progression in malignant bladder cancer cells in vitro and in vivo
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/180801
_version_	1779152713230057472

The investigational aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell-cycle progression in malignant bladder cancer cells in vitro and in vivo

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