The investigational aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell-cycle progression in malignant bladder cancer cells in vitro and in vivo

The investigational aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell-cycle progression in malignant bladder cancer cells in vitro and in vivo

10.1158/1078-0432.CCR-12-2383

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Bibliographic Details
Main Authors:	Zhou, N, Singh, K, Mir, M.C, Parker, Y, Lindner, D, Dreicer, R, Ecsedy, J.A, Zhang, Z, Teh, B.T, Almasan, A, Hansel, D.E
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	2020
Subjects:	alisertib gemcitabine paclitaxel aneuploidy animal experiment animal model antineoplastic activity apoptosis article bladder papilloma cancer inhibition cell cycle arrest controlled study drug cytotoxicity drug potentiation gene expression regulation gene overexpression gene sequence human human cell in vitro study in vivo study microarray analysis mouse nonhuman priority journal reverse transcription polymerase chain reaction upregulation Aneuploidy Animals Apoptosis Azepines Cell Cycle Cell Cycle Checkpoints Cell Line, Tumor Cell Survival Cluster Analysis Deoxycytidine Drug Synergism Gene Expression Gene Expression Profiling Humans M Phase Cell Cycle Checkpoints Mice Neoplasm Invasiveness Paclitaxel Phenotype Protein-Serine-Threonine Kinases Pyrimidines Tumor Burden Urinary Bladder Neoplasms Xenograft Model Antitumor Assays
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/180801
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Institution:	National University of Singapore

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