Artemin is hypoxia responsive and promotes oncogenicity and increased tumor initiating capacity in hepatocellular carcinoma

• Main Authors: Zhang, M, Zhang, W, Wu, Z, Liu, S, Sun, L, Zhong, Y, Zhang, X, Kong, X, Qian, P, Zhang, H, Lobie, P.E, Zhu, T
• Other Authors: DEPT OF PHARMACOLOGY
• Format: Article
• Published: 2020
• Subjects: artemin; CD133 antigen; hypoxia inducible factor 1alpha; protein kinase B; ARTN protein, human; HIF1A protein, human; messenger RNA; nerve protein; apoptosis; Article; cancer growth; cancer stem cell; cancer survival; carcinogenicity; cell expansion; cell hypoxia; cell motility; cell population; cell proliferation; controlled study; epithelial mesenchymal transition; human; human cell; in vitro study; in vivo study; liver cell carcinoma; protein targeting; signal transduction; tumor invasion; tumor volume; animal; Bagg albino mouse; cell transformation; drug screening; enzyme immunoassay; fluorescent antibody technique; genetics; hypoxia; liver tumor; male; metabolism; mouse; nude mouse; pathology; pathophysiology; prognosis; real time polymerase chain reaction; reverse transcription polymerase chain reaction; tumor cell culture; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Cell Transformation, Neoplastic; Epithelial-Mesenchymal Transition; Fluorescent Antibody Technique; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoenzyme Techniques; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplastic Stem Cells; Nerve Tissue Proteins; Prognosis; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Xenograft Model Antitumor Assays
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/180860
• Institution: National University of Singapore

10.18632/oncotarget.6572