Pre-differentiation of human neural stem cells into GABAergic neurons prior to transplant results in greater repopulation of the damaged brain and accelerates functional recovery after transient ischemic stroke

• Main Authors: Abeysinghe, H.C.S, Bokhari, L, Quigley, A, Choolani, M, Chan, J, Dusting, G.J, Crook, J.M, Kobayashi, N.R, Roulston, C.L
• Other Authors: OBSTETRICS & GYNAECOLOGY
• Format: Article
• Published: 2020
• Subjects: glial fibrillary acidic protein; 4 aminobutyric acid receptor; adult; animal experiment; animal model; animal tissue; Article; astrocyte; cell maturation; cell survival; confocal microscopy; controlled study; fetus; GABAergic system; histopathology; human; human cell; immunohistochemistry; male; motor performance; nerve cell differentiation; neural stem cell; neurotransmission; nonhuman; outcome assessment; priority journal; protein expression; rat; stem cell transplantation; stereotactic treatment; subventricular zone; synaptogenesis; transient ischemic attack; animal; brain cortex; cell culture; convalescence; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; metabolism; motor activity; nervous system development; pathology; pathophysiology; physiology; transplantation; Wistar rat; Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; GABAergic Neurons; Male; Motor Activity; Neural Stem Cells; Neurogenesis; Rats, Wistar; Recovery of Function
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/180883
• Institution: National University of Singapore

10.1186/s13287-015-0175-1