Pre-differentiation of human neural stem cells into GABAergic neurons prior to transplant results in greater repopulation of the damaged brain and accelerates functional recovery after transient ischemic stroke

10.1186/s13287-015-0175-1

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Main Authors:	Abeysinghe, H.C.S, Bokhari, L, Quigley, A, Choolani, M, Chan, J, Dusting, G.J, Crook, J.M, Kobayashi, N.R, Roulston, C.L
Other Authors:	OBSTETRICS & GYNAECOLOGY
Format:	Article
Published:	2020
Subjects:	glial fibrillary acidic protein 4 aminobutyric acid receptor adult animal experiment animal model animal tissue Article astrocyte cell maturation cell survival confocal microscopy controlled study fetus GABAergic system histopathology human human cell immunohistochemistry male motor performance nerve cell differentiation neural stem cell neurotransmission nonhuman outcome assessment priority journal protein expression rat stem cell transplantation stereotactic treatment subventricular zone synaptogenesis transient ischemic attack animal brain cortex cell culture convalescence Infarction, Middle Cerebral Artery Ischemic Attack, Transient metabolism motor activity nervous system development pathology pathophysiology physiology transplantation Wistar rat Animals Cell Survival Cells, Cultured Cerebral Cortex GABAergic Neurons Male Motor Activity Neural Stem Cells Neurogenesis Rats, Wistar Recovery of Function
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/180883
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1808832024-04-11T05:57:37Z Pre-differentiation of human neural stem cells into GABAergic neurons prior to transplant results in greater repopulation of the damaged brain and accelerates functional recovery after transient ischemic stroke Abeysinghe, H.C.S Bokhari, L Quigley, A Choolani, M Chan, J Dusting, G.J Crook, J.M Kobayashi, N.R Roulston, C.L OBSTETRICS & GYNAECOLOGY DUKE-NUS MEDICAL SCHOOL glial fibrillary acidic protein 4 aminobutyric acid receptor adult animal experiment animal model animal tissue Article astrocyte cell maturation cell survival confocal microscopy controlled study fetus GABAergic system histopathology human human cell immunohistochemistry male motor performance nerve cell differentiation neural stem cell neurotransmission nonhuman outcome assessment priority journal protein expression rat stem cell transplantation stereotactic treatment subventricular zone synaptogenesis transient ischemic attack animal brain cortex cell culture convalescence Infarction, Middle Cerebral Artery Ischemic Attack, Transient metabolism motor activity nervous system development neural stem cell pathology pathophysiology physiology transplantation Wistar rat Animals Cell Survival Cells, Cultured Cerebral Cortex GABAergic Neurons Infarction, Middle Cerebral Artery Ischemic Attack, Transient Male Motor Activity Neural Stem Cells Neurogenesis Rats, Wistar Recovery of Function 10.1186/s13287-015-0175-1 Stem Cell Research and Therapy 6 1 186 2020-10-27T05:36:31Z 2020-10-27T05:36:31Z 2015 Article Abeysinghe, H.C.S, Bokhari, L, Quigley, A, Choolani, M, Chan, J, Dusting, G.J, Crook, J.M, Kobayashi, N.R, Roulston, C.L (2015). Pre-differentiation of human neural stem cells into GABAergic neurons prior to transplant results in greater repopulation of the damaged brain and accelerates functional recovery after transient ischemic stroke. Stem Cell Research and Therapy 6 (1) : 186. ScholarBank@NUS Repository. https://doi.org/10.1186/s13287-015-0175-1 17576512 https://scholarbank.nus.edu.sg/handle/10635/180883 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	glial fibrillary acidic protein 4 aminobutyric acid receptor adult animal experiment animal model animal tissue Article astrocyte cell maturation cell survival confocal microscopy controlled study fetus GABAergic system histopathology human human cell immunohistochemistry male motor performance nerve cell differentiation neural stem cell neurotransmission nonhuman outcome assessment priority journal protein expression rat stem cell transplantation stereotactic treatment subventricular zone synaptogenesis transient ischemic attack animal brain cortex cell culture convalescence Infarction, Middle Cerebral Artery Ischemic Attack, Transient metabolism motor activity nervous system development neural stem cell pathology pathophysiology physiology transplantation Wistar rat Animals Cell Survival Cells, Cultured Cerebral Cortex GABAergic Neurons Infarction, Middle Cerebral Artery Ischemic Attack, Transient Male Motor Activity Neural Stem Cells Neurogenesis Rats, Wistar Recovery of Function
spellingShingle	glial fibrillary acidic protein 4 aminobutyric acid receptor adult animal experiment animal model animal tissue Article astrocyte cell maturation cell survival confocal microscopy controlled study fetus GABAergic system histopathology human human cell immunohistochemistry male motor performance nerve cell differentiation neural stem cell neurotransmission nonhuman outcome assessment priority journal protein expression rat stem cell transplantation stereotactic treatment subventricular zone synaptogenesis transient ischemic attack animal brain cortex cell culture convalescence Infarction, Middle Cerebral Artery Ischemic Attack, Transient metabolism motor activity nervous system development neural stem cell pathology pathophysiology physiology transplantation Wistar rat Animals Cell Survival Cells, Cultured Cerebral Cortex GABAergic Neurons Infarction, Middle Cerebral Artery Ischemic Attack, Transient Male Motor Activity Neural Stem Cells Neurogenesis Rats, Wistar Recovery of Function Abeysinghe, H.C.S Bokhari, L Quigley, A Choolani, M Chan, J Dusting, G.J Crook, J.M Kobayashi, N.R Roulston, C.L Pre-differentiation of human neural stem cells into GABAergic neurons prior to transplant results in greater repopulation of the damaged brain and accelerates functional recovery after transient ischemic stroke
description	10.1186/s13287-015-0175-1
author2	OBSTETRICS & GYNAECOLOGY
author_facet	OBSTETRICS & GYNAECOLOGY Abeysinghe, H.C.S Bokhari, L Quigley, A Choolani, M Chan, J Dusting, G.J Crook, J.M Kobayashi, N.R Roulston, C.L
format	Article
author	Abeysinghe, H.C.S Bokhari, L Quigley, A Choolani, M Chan, J Dusting, G.J Crook, J.M Kobayashi, N.R Roulston, C.L
author_sort	Abeysinghe, H.C.S
title	Pre-differentiation of human neural stem cells into GABAergic neurons prior to transplant results in greater repopulation of the damaged brain and accelerates functional recovery after transient ischemic stroke
title_short	Pre-differentiation of human neural stem cells into GABAergic neurons prior to transplant results in greater repopulation of the damaged brain and accelerates functional recovery after transient ischemic stroke
title_full	Pre-differentiation of human neural stem cells into GABAergic neurons prior to transplant results in greater repopulation of the damaged brain and accelerates functional recovery after transient ischemic stroke
title_fullStr	Pre-differentiation of human neural stem cells into GABAergic neurons prior to transplant results in greater repopulation of the damaged brain and accelerates functional recovery after transient ischemic stroke
title_full_unstemmed	Pre-differentiation of human neural stem cells into GABAergic neurons prior to transplant results in greater repopulation of the damaged brain and accelerates functional recovery after transient ischemic stroke
title_sort	pre-differentiation of human neural stem cells into gabaergic neurons prior to transplant results in greater repopulation of the damaged brain and accelerates functional recovery after transient ischemic stroke
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/180883
_version_	1800914613879963648

Pre-differentiation of human neural stem cells into GABAergic neurons prior to transplant results in greater repopulation of the damaged brain and accelerates functional recovery after transient ischemic stroke

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