HPV16-E2 induces prophase arrest and activates the cellular DNA damage response in vitro and in precursor lesions of cervical carcinoma

• Main Authors: Xue, Y, Toh, S.Y, He, P, Lim, T, Lim, D, Pang, C.L, Abastado, J.-P, Thierry, F
• Other Authors: PATHOLOGY
• Format: Article
• Published: 2020
• Subjects: DNA; unclassified drug; virus E2 protein; virus protein; DNA binding protein; E2 protein, Human papillomavirus type 16; oncoprotein; Article; cell cycle arrest; cell cycle regulation; controlled study; DNA damage; DNA repair; female; genomic instability; human; human cell; Human papillomavirus type 16; human tissue; in vitro study; in vivo study; major clinical study; malignant transformation; nonhuman; prophase; protein expression; uterine cervix carcinoma in situ; virus carcinogenesis; virus cell interaction; cell cycle checkpoint; cell transformation; complication; flow cytometry; fluorescent antibody technique; immunohistochemistry; immunoprecipitation; in situ hybridization; metabolism; papillomavirus infection; pathology; physiology; precancer; uterine cervix tumor; virology; Western blotting; Blotting, Western; Cell Cycle Checkpoints; Cell Transformation, Neoplastic; Cervical Intraepithelial Neoplasia; DNA Damage; DNA-Binding Proteins; Female; Flow Cytometry; Fluorescent Antibody Technique; Humans; Immunohistochemistry; Immunoprecipitation; In Situ Hybridization; Oncogene Proteins, Viral; Papillomavirus Infections; Precancerous Conditions; Prophase; Uterine Cervical Neoplasms
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/180931
• Institution: National University of Singapore

10.18632/oncotarget.5512