Administration of PDE4 inhibitors suppressed the pannus-like inflammation by inhibition of cytokine production by macrophages and synovial fibroblast proliferation

10.1155/2007/58901

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Bibliographic Details
Main Authors:	Kobayashi, K, Suda, T, Manabe, H, Miki, I
Other Authors:	MEDICINE
Format:	Article
Published:	2020
Subjects:	bovine serum albumin cilomilast diclofenac hydroxyproline interleukin 12 interleukin 1beta kf 66490 leflunomide lipopolysaccharide methotrexate myeloperoxidase phosphodiesterase IV inhibitor prednisolone thioglycolic acid tumor necrosis factor alpha unclassified drug cytokine phosphodiesterase IV animal experiment animal model animal tissue article cell proliferation controlled study cytokine production drug mechanism enzyme activity granuloma inflammation macrophage male mouse nonhuman priority journal rheumatoid arthritis animal Bagg albino mouse drug antagonism fibroblast metabolism oral drug administration subcutaneous drug administration synovium Animalia Bovinae Murinae Mus Rattus Administration, Oral Animals Arthritis, Rheumatoid Cell Proliferation Cyclic Nucleotide Phosphodiesterases, Type 4 Cytokines Fibroblasts Inflammation Injections, Subcutaneous Macrophages Male Mice Mice, Inbred BALB C Serum Albumin, Bovine Synovial Membrane
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/181029
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Institution:	National University of Singapore

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