Administration of PDE4 inhibitors suppressed the pannus-like inflammation by inhibition of cytokine production by macrophages and synovial fibroblast proliferation

10.1155/2007/58901

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Main Authors:	Kobayashi, K, Suda, T, Manabe, H, Miki, I
Other Authors:	MEDICINE
Format:	Article
Published:	2020
Subjects:	bovine serum albumin cilomilast diclofenac hydroxyproline interleukin 12 interleukin 1beta kf 66490 leflunomide lipopolysaccharide methotrexate myeloperoxidase phosphodiesterase IV inhibitor prednisolone thioglycolic acid tumor necrosis factor alpha unclassified drug cytokine phosphodiesterase IV animal experiment animal model animal tissue article cell proliferation controlled study cytokine production drug mechanism enzyme activity granuloma inflammation macrophage male mouse nonhuman priority journal rheumatoid arthritis animal Bagg albino mouse drug antagonism fibroblast metabolism oral drug administration subcutaneous drug administration synovium Animalia Bovinae Murinae Mus Rattus Administration, Oral Animals Arthritis, Rheumatoid Cell Proliferation Cyclic Nucleotide Phosphodiesterases, Type 4 Cytokines Fibroblasts Inflammation Injections, Subcutaneous Macrophages Male Mice Mice, Inbred BALB C Serum Albumin, Bovine Synovial Membrane
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/181029
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Institution:	National University of Singapore

id	sg-nus-scholar.10635-181029
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spelling	sg-nus-scholar.10635-1810292024-04-24T05:51:35Z Administration of PDE4 inhibitors suppressed the pannus-like inflammation by inhibition of cytokine production by macrophages and synovial fibroblast proliferation Kobayashi, K Suda, T Manabe, H Miki, I MEDICINE bovine serum albumin cilomilast diclofenac hydroxyproline interleukin 12 interleukin 1beta kf 66490 leflunomide lipopolysaccharide methotrexate myeloperoxidase phosphodiesterase IV inhibitor prednisolone thioglycolic acid tumor necrosis factor alpha unclassified drug cytokine phosphodiesterase IV animal experiment animal model animal tissue article cell proliferation controlled study cytokine production drug mechanism enzyme activity granuloma inflammation macrophage male mouse nonhuman priority journal rheumatoid arthritis animal Bagg albino mouse drug antagonism fibroblast inflammation macrophage metabolism oral drug administration subcutaneous drug administration synovium Animalia Bovinae Murinae Mus Rattus Administration, Oral Animals Arthritis, Rheumatoid Cell Proliferation Cyclic Nucleotide Phosphodiesterases, Type 4 Cytokines Fibroblasts Inflammation Injections, Subcutaneous Macrophages Male Mice Mice, Inbred BALB C Serum Albumin, Bovine Synovial Membrane 10.1155/2007/58901 Mediators of Inflammation 2007 58901 2020-10-27T06:57:34Z 2020-10-27T06:57:34Z 2007 Article Kobayashi, K, Suda, T, Manabe, H, Miki, I (2007). Administration of PDE4 inhibitors suppressed the pannus-like inflammation by inhibition of cytokine production by macrophages and synovial fibroblast proliferation. Mediators of Inflammation 2007 : 58901. ScholarBank@NUS Repository. https://doi.org/10.1155/2007/58901 0962-9351 https://scholarbank.nus.edu.sg/handle/10635/181029 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	bovine serum albumin cilomilast diclofenac hydroxyproline interleukin 12 interleukin 1beta kf 66490 leflunomide lipopolysaccharide methotrexate myeloperoxidase phosphodiesterase IV inhibitor prednisolone thioglycolic acid tumor necrosis factor alpha unclassified drug cytokine phosphodiesterase IV animal experiment animal model animal tissue article cell proliferation controlled study cytokine production drug mechanism enzyme activity granuloma inflammation macrophage male mouse nonhuman priority journal rheumatoid arthritis animal Bagg albino mouse drug antagonism fibroblast inflammation macrophage metabolism oral drug administration subcutaneous drug administration synovium Animalia Bovinae Murinae Mus Rattus Administration, Oral Animals Arthritis, Rheumatoid Cell Proliferation Cyclic Nucleotide Phosphodiesterases, Type 4 Cytokines Fibroblasts Inflammation Injections, Subcutaneous Macrophages Male Mice Mice, Inbred BALB C Serum Albumin, Bovine Synovial Membrane
spellingShingle	bovine serum albumin cilomilast diclofenac hydroxyproline interleukin 12 interleukin 1beta kf 66490 leflunomide lipopolysaccharide methotrexate myeloperoxidase phosphodiesterase IV inhibitor prednisolone thioglycolic acid tumor necrosis factor alpha unclassified drug cytokine phosphodiesterase IV animal experiment animal model animal tissue article cell proliferation controlled study cytokine production drug mechanism enzyme activity granuloma inflammation macrophage male mouse nonhuman priority journal rheumatoid arthritis animal Bagg albino mouse drug antagonism fibroblast inflammation macrophage metabolism oral drug administration subcutaneous drug administration synovium Animalia Bovinae Murinae Mus Rattus Administration, Oral Animals Arthritis, Rheumatoid Cell Proliferation Cyclic Nucleotide Phosphodiesterases, Type 4 Cytokines Fibroblasts Inflammation Injections, Subcutaneous Macrophages Male Mice Mice, Inbred BALB C Serum Albumin, Bovine Synovial Membrane Kobayashi, K Suda, T Manabe, H Miki, I Administration of PDE4 inhibitors suppressed the pannus-like inflammation by inhibition of cytokine production by macrophages and synovial fibroblast proliferation
description	10.1155/2007/58901
author2	MEDICINE
author_facet	MEDICINE Kobayashi, K Suda, T Manabe, H Miki, I
format	Article
author	Kobayashi, K Suda, T Manabe, H Miki, I
author_sort	Kobayashi, K
title	Administration of PDE4 inhibitors suppressed the pannus-like inflammation by inhibition of cytokine production by macrophages and synovial fibroblast proliferation
title_short	Administration of PDE4 inhibitors suppressed the pannus-like inflammation by inhibition of cytokine production by macrophages and synovial fibroblast proliferation
title_full	Administration of PDE4 inhibitors suppressed the pannus-like inflammation by inhibition of cytokine production by macrophages and synovial fibroblast proliferation
title_fullStr	Administration of PDE4 inhibitors suppressed the pannus-like inflammation by inhibition of cytokine production by macrophages and synovial fibroblast proliferation
title_full_unstemmed	Administration of PDE4 inhibitors suppressed the pannus-like inflammation by inhibition of cytokine production by macrophages and synovial fibroblast proliferation
title_sort	administration of pde4 inhibitors suppressed the pannus-like inflammation by inhibition of cytokine production by macrophages and synovial fibroblast proliferation
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/181029
_version_	1800914621400350720

Administration of PDE4 inhibitors suppressed the pannus-like inflammation by inhibition of cytokine production by macrophages and synovial fibroblast proliferation

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