VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail

• Main Authors: Evans, A.J, Russell, R.C, Roche, O, Burry, T.N, Fish, J.E, Chow, V.W.K, Kim, W.Y, Saravanan, A, Maynard, M.A, Gervais, M.L, Sufan, R.I, Roberts, A.M, Wilson, L.A, Betten, M, Vandewalle, C, Berx, G, Marsden, P.A, Irwin, M.S, Teh, B.T, Jewett, M.A.S, Ohh, M
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2020
• Subjects: cell adhesion molecule; gene product; hypoxia inducible factor; mutant protein; oxygen; RNA polymerase II; transcription factor; transcription factor SIP1; transcription factor Snail; tumor suppressor protein; ubiquitin protein ligase E3; unclassified drug; uvomorulin; von Hippel Lindau protein; alpha chain; article; cell junction; clear cell carcinoma; controlled study; down regulation; enzyme active site; enzyme substrate; epithelium cell; gene expression regulation; gene loss; gene overexpression; gene repression; genetic transfection; human; human cell; human tissue; hypoxia; kidney carcinoma; kidney epithelium; knockout gene; nucleotide sequence; priority journal; promoter region; protein degradation; protein expression; protein function; RNA interference; transcription regulation; ubiquitination; upregulation; Cadherins; Cell Line, Tumor; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney; Nerve Tissue Proteins; Promoter Regions (Genetics); RNA Interference; RNA Polymerase II; RNA, Small Interfering; RNA-Binding Proteins; Subcellular Fractions; Transcription Factors; Von Hippel-Lindau Tumor Suppressor Protein; Gastropoda; Pyronia tithonus
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/181050
• Institution: National University of Singapore

10.1128/MCB.00892-06