Tumor suppressor activity and epigenetic inactivation of hepatocyte growth factor activator inhibitor type 2/SPINT2 in papillary and clear cell renal cell carcinoma

• Main Authors: Morris, M.R, Gentle, D, Abdulrahman, M, Maina, E.N, Gupta, K, Banks, R.E, Wiesener, M.S, Kishida, T, Yao, M, Teh, B, Lauf, F, Maher, E.R
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2020
• Subjects: 1 [[6 (3 methoxyestra 1,3,5(10) trien 17beta yl)amino]hexyl] 1h pyrrole 2,5 dione; 1,4 diamino 1,4 bis(2 aminophenylthio) 2,3 dicyanobutadiene; 2 (2 amino 3 methoxyphenyl)chromone; 2 [1 (3 dimethylaminopropyl) 3 indolyl] 3 (3 indolyl)maleimide; mitogen activated protein kinase inhibitor; phospholipase C inhibitor; protein kinase C inhibitor; scatter factor; ulinastatin; article; cancer inhibition; carcinogenesis; cell motility; clear cell carcinoma; controlled study; down regulation; drug activity; epigenetics; gene identification; gene inactivation; gene silencing; human; human cell; kidney carcinoma; methylation; missense mutation; mutational analysis; papillary carcinoma; polymerase chain reaction; priority journal; promoter region; protein expression; signal transduction; tumor suppressor gene; Adenocarcinoma, Clear Cell; Animals; Base Sequence; Carcinoma, Papillary; Carcinoma, Renal Cell; Cell Adhesion; Cell Growth Processes; Cell Line, Tumor; Cell Movement; Cercopithecus aethiops; COS Cells; DNA Methylation; Down-Regulation; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Humans; Kidney Neoplasms; Membrane Glycoproteins; Molecular Sequence Data; Promoter Regions (Genetics); Proto-Oncogene Proteins; Receptors, Growth Factor; Signal Transduction; Trypsin Inhibitor, Kunitz Soybean; Tumor Stem Cells
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/181091
• Institution: National University of Singapore

10.1158/0008-5472.CAN-04-3371