Elevated physiologic tumor pressure promotes proliferation and chemosensitivity in human osteosarcoma

• Main Authors: Nathan, S.S, DiResta, G.R, Casas-Ganem, J.E, Hoang, B.H, Sowers, R, Yang, R, Huvos, A.G, Gorlick, R, Healey, J.H
• Other Authors: ORTHOPAEDIC SURGERY
• Format: Article
• Published: 2020
• Subjects: cisplatin; doxorubicin; ifosfamide; methotrexate; transcription factor E2F1; transcription factor E2F4; adolescent; adult; article; blood flow; cancer cell; cancer chemotherapy; cancer growth; cancer surgery; cancer survival; cell cycle S phase; cell proliferation; chemosensitivity; clinical article; controlled study; correlation analysis; Doppler flowmetry; female; human; human cell; hydrostatic pressure; male; osteosarcoma; osteosarcoma cell; priority journal; school child; tissue pressure; tumor biopsy; tumor necrosis; Adolescent; Adult; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Atmospheric Pressure; Blood Flow Velocity; Bone Neoplasms; Cell Proliferation; Child; Cisplatin; Doxorubicin; Drug Resistance, Neoplasm; Extracellular Fluid; Female; Humans; Male; Middle Aged; Necrosis; Osteosarcoma; S Phase; Survival Rate; Tumor Cells, Cultured
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/181094
• Institution: National University of Singapore

10.1158/1078-0432.CCR-04-2048