Autophagy governs protumorigenic effects of mitotic slippage-induced senescence

10.1158/1541-7786.MCR-18-0024

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Main Authors:	Jakhar, R, Luijten, M.N.H, Wong, A.X.F, Cheng, B, Guo, K, Neo, S.P, Au, B, Kulkarni, M, Lim, K.J, Maimaiti, J, Chong, H.C, Lim, E.H, Tan, T.B.K, Ong, K.W, Sim, Y, Wong, J.S.L, Khoo, J.B.K, Ho, J.T.S, Chua, B.T, Sinha, I, Wang, X, Connolly, J.E, Gunaratne, J, Crasta, K.C
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	2020
Subjects:	antimitotic agent antineoplastic agent autophagy related protein 5 biological marker chloroquine hydroxymethylglutaryl coenzyme A reductase kinase nocodazole paclitaxel protein protein p53 protein PERK unclassified drug AMP-activated protein kinase kinase cytokine protein kinase animal experiment animal model apoptosis Article autophagy cancer inhibition carcinogenesis cell death cell fate cell invasion cell migration controlled study DNA damage endoplasmic reticulum stress enzyme activation escape behavior G1 phase cell cycle checkpoint gene silencing human human cell human tissue interphase microtubule mitosis mitosis inhibition mitotic slippage mouse nonhuman paracrine signaling phenotype priority journal S phase cell cycle checkpoint senescence tetraploidy tumor growth vascularization animal Bagg albino mouse bone tumor cell aging colon tumor drug effect female genetic transfection HCT 116 cell line HEK293 cell line MCF-7 cell line metabolism neoplasm nude mouse osteosarcoma pancreas tumor pathology physiology xenograft zebra fish Animals Antineoplastic Combined Chemotherapy Protocols Autophagy Bone Neoplasms Cellular Senescence Colonic Neoplasms Cytokines Female HCT116 Cells HEK293 Cells Heterografts Humans MCF-7 Cells Mice Mice, Inbred BALB C Mice, Nude Mitosis Neoplasms Osteosarcoma Pancreatic Neoplasms Protein Kinases Transfection Zebrafish
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/181172
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1811722024-04-08T14:38:44Z Autophagy governs protumorigenic effects of mitotic slippage-induced senescence Jakhar, R Luijten, M.N.H Wong, A.X.F Cheng, B Guo, K Neo, S.P Au, B Kulkarni, M Lim, K.J Maimaiti, J Chong, H.C Lim, E.H Tan, T.B.K Ong, K.W Sim, Y Wong, J.S.L Khoo, J.B.K Ho, J.T.S Chua, B.T Sinha, I Wang, X Connolly, J.E Gunaratne, J Crasta, K.C DUKE-NUS MEDICAL SCHOOL MICROBIOLOGY AND IMMUNOLOGY ANATOMY antimitotic agent antineoplastic agent autophagy related protein 5 biological marker chloroquine hydroxymethylglutaryl coenzyme A reductase kinase nocodazole paclitaxel protein protein p53 protein PERK unclassified drug AMP-activated protein kinase kinase antineoplastic agent cytokine protein kinase animal experiment animal model apoptosis Article autophagy cancer inhibition carcinogenesis cell death cell fate cell invasion cell migration controlled study DNA damage endoplasmic reticulum stress enzyme activation escape behavior G1 phase cell cycle checkpoint gene silencing human human cell human tissue interphase microtubule mitosis mitosis inhibition mitotic slippage mouse nonhuman paracrine signaling phenotype priority journal S phase cell cycle checkpoint senescence tetraploidy tumor growth vascularization animal autophagy Bagg albino mouse bone tumor cell aging colon tumor drug effect female genetic transfection HCT 116 cell line HEK293 cell line MCF-7 cell line metabolism mitosis neoplasm nude mouse osteosarcoma pancreas tumor pathology physiology xenograft zebra fish Animals Antineoplastic Combined Chemotherapy Protocols Autophagy Bone Neoplasms Cellular Senescence Colonic Neoplasms Cytokines Female HCT116 Cells HEK293 Cells Heterografts Humans MCF-7 Cells Mice Mice, Inbred BALB C Mice, Nude Mitosis Neoplasms Osteosarcoma Pancreatic Neoplasms Protein Kinases Transfection Zebrafish 10.1158/1541-7786.MCR-18-0024 Molecular Cancer Research 16 11 1625-1640 2020-10-27T10:05:14Z 2020-10-27T10:05:14Z 2018 Article Jakhar, R, Luijten, M.N.H, Wong, A.X.F, Cheng, B, Guo, K, Neo, S.P, Au, B, Kulkarni, M, Lim, K.J, Maimaiti, J, Chong, H.C, Lim, E.H, Tan, T.B.K, Ong, K.W, Sim, Y, Wong, J.S.L, Khoo, J.B.K, Ho, J.T.S, Chua, B.T, Sinha, I, Wang, X, Connolly, J.E, Gunaratne, J, Crasta, K.C (2018). Autophagy governs protumorigenic effects of mitotic slippage-induced senescence. Molecular Cancer Research 16 (11) : 1625-1640. ScholarBank@NUS Repository. https://doi.org/10.1158/1541-7786.MCR-18-0024 15417786 https://scholarbank.nus.edu.sg/handle/10635/181172 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	antimitotic agent antineoplastic agent autophagy related protein 5 biological marker chloroquine hydroxymethylglutaryl coenzyme A reductase kinase nocodazole paclitaxel protein protein p53 protein PERK unclassified drug AMP-activated protein kinase kinase antineoplastic agent cytokine protein kinase animal experiment animal model apoptosis Article autophagy cancer inhibition carcinogenesis cell death cell fate cell invasion cell migration controlled study DNA damage endoplasmic reticulum stress enzyme activation escape behavior G1 phase cell cycle checkpoint gene silencing human human cell human tissue interphase microtubule mitosis mitosis inhibition mitotic slippage mouse nonhuman paracrine signaling phenotype priority journal S phase cell cycle checkpoint senescence tetraploidy tumor growth vascularization animal autophagy Bagg albino mouse bone tumor cell aging colon tumor drug effect female genetic transfection HCT 116 cell line HEK293 cell line MCF-7 cell line metabolism mitosis neoplasm nude mouse osteosarcoma pancreas tumor pathology physiology xenograft zebra fish Animals Antineoplastic Combined Chemotherapy Protocols Autophagy Bone Neoplasms Cellular Senescence Colonic Neoplasms Cytokines Female HCT116 Cells HEK293 Cells Heterografts Humans MCF-7 Cells Mice Mice, Inbred BALB C Mice, Nude Mitosis Neoplasms Osteosarcoma Pancreatic Neoplasms Protein Kinases Transfection Zebrafish
spellingShingle	antimitotic agent antineoplastic agent autophagy related protein 5 biological marker chloroquine hydroxymethylglutaryl coenzyme A reductase kinase nocodazole paclitaxel protein protein p53 protein PERK unclassified drug AMP-activated protein kinase kinase antineoplastic agent cytokine protein kinase animal experiment animal model apoptosis Article autophagy cancer inhibition carcinogenesis cell death cell fate cell invasion cell migration controlled study DNA damage endoplasmic reticulum stress enzyme activation escape behavior G1 phase cell cycle checkpoint gene silencing human human cell human tissue interphase microtubule mitosis mitosis inhibition mitotic slippage mouse nonhuman paracrine signaling phenotype priority journal S phase cell cycle checkpoint senescence tetraploidy tumor growth vascularization animal autophagy Bagg albino mouse bone tumor cell aging colon tumor drug effect female genetic transfection HCT 116 cell line HEK293 cell line MCF-7 cell line metabolism mitosis neoplasm nude mouse osteosarcoma pancreas tumor pathology physiology xenograft zebra fish Animals Antineoplastic Combined Chemotherapy Protocols Autophagy Bone Neoplasms Cellular Senescence Colonic Neoplasms Cytokines Female HCT116 Cells HEK293 Cells Heterografts Humans MCF-7 Cells Mice Mice, Inbred BALB C Mice, Nude Mitosis Neoplasms Osteosarcoma Pancreatic Neoplasms Protein Kinases Transfection Zebrafish Jakhar, R Luijten, M.N.H Wong, A.X.F Cheng, B Guo, K Neo, S.P Au, B Kulkarni, M Lim, K.J Maimaiti, J Chong, H.C Lim, E.H Tan, T.B.K Ong, K.W Sim, Y Wong, J.S.L Khoo, J.B.K Ho, J.T.S Chua, B.T Sinha, I Wang, X Connolly, J.E Gunaratne, J Crasta, K.C Autophagy governs protumorigenic effects of mitotic slippage-induced senescence
description	10.1158/1541-7786.MCR-18-0024
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Jakhar, R Luijten, M.N.H Wong, A.X.F Cheng, B Guo, K Neo, S.P Au, B Kulkarni, M Lim, K.J Maimaiti, J Chong, H.C Lim, E.H Tan, T.B.K Ong, K.W Sim, Y Wong, J.S.L Khoo, J.B.K Ho, J.T.S Chua, B.T Sinha, I Wang, X Connolly, J.E Gunaratne, J Crasta, K.C
format	Article
author	Jakhar, R Luijten, M.N.H Wong, A.X.F Cheng, B Guo, K Neo, S.P Au, B Kulkarni, M Lim, K.J Maimaiti, J Chong, H.C Lim, E.H Tan, T.B.K Ong, K.W Sim, Y Wong, J.S.L Khoo, J.B.K Ho, J.T.S Chua, B.T Sinha, I Wang, X Connolly, J.E Gunaratne, J Crasta, K.C
author_sort	Jakhar, R
title	Autophagy governs protumorigenic effects of mitotic slippage-induced senescence
title_short	Autophagy governs protumorigenic effects of mitotic slippage-induced senescence
title_full	Autophagy governs protumorigenic effects of mitotic slippage-induced senescence
title_fullStr	Autophagy governs protumorigenic effects of mitotic slippage-induced senescence
title_full_unstemmed	Autophagy governs protumorigenic effects of mitotic slippage-induced senescence
title_sort	autophagy governs protumorigenic effects of mitotic slippage-induced senescence
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/181172
_version_	1800914625860993024

Autophagy governs protumorigenic effects of mitotic slippage-induced senescence

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