Autophagy governs protumorigenic effects of mitotic slippage-induced senescence

10.1158/1541-7786.MCR-18-0024

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Main Authors: Jakhar, R, Luijten, M.N.H, Wong, A.X.F, Cheng, B, Guo, K, Neo, S.P, Au, B, Kulkarni, M, Lim, K.J, Maimaiti, J, Chong, H.C, Lim, E.H, Tan, T.B.K, Ong, K.W, Sim, Y, Wong, J.S.L, Khoo, J.B.K, Ho, J.T.S, Chua, B.T, Sinha, I, Wang, X, Connolly, J.E, Gunaratne, J, Crasta, K.C
Other Authors: DUKE-NUS MEDICAL SCHOOL
Format: Article
Published: 2020
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Online Access:https://scholarbank.nus.edu.sg/handle/10635/181172
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spelling sg-nus-scholar.10635-1811722024-04-08T14:38:44Z Autophagy governs protumorigenic effects of mitotic slippage-induced senescence Jakhar, R Luijten, M.N.H Wong, A.X.F Cheng, B Guo, K Neo, S.P Au, B Kulkarni, M Lim, K.J Maimaiti, J Chong, H.C Lim, E.H Tan, T.B.K Ong, K.W Sim, Y Wong, J.S.L Khoo, J.B.K Ho, J.T.S Chua, B.T Sinha, I Wang, X Connolly, J.E Gunaratne, J Crasta, K.C DUKE-NUS MEDICAL SCHOOL MICROBIOLOGY AND IMMUNOLOGY ANATOMY antimitotic agent antineoplastic agent autophagy related protein 5 biological marker chloroquine hydroxymethylglutaryl coenzyme A reductase kinase nocodazole paclitaxel protein protein p53 protein PERK unclassified drug AMP-activated protein kinase kinase antineoplastic agent cytokine protein kinase animal experiment animal model apoptosis Article autophagy cancer inhibition carcinogenesis cell death cell fate cell invasion cell migration controlled study DNA damage endoplasmic reticulum stress enzyme activation escape behavior G1 phase cell cycle checkpoint gene silencing human human cell human tissue interphase microtubule mitosis mitosis inhibition mitotic slippage mouse nonhuman paracrine signaling phenotype priority journal S phase cell cycle checkpoint senescence tetraploidy tumor growth vascularization animal autophagy Bagg albino mouse bone tumor cell aging colon tumor drug effect female genetic transfection HCT 116 cell line HEK293 cell line MCF-7 cell line metabolism mitosis neoplasm nude mouse osteosarcoma pancreas tumor pathology physiology xenograft zebra fish Animals Antineoplastic Combined Chemotherapy Protocols Autophagy Bone Neoplasms Cellular Senescence Colonic Neoplasms Cytokines Female HCT116 Cells HEK293 Cells Heterografts Humans MCF-7 Cells Mice Mice, Inbred BALB C Mice, Nude Mitosis Neoplasms Osteosarcoma Pancreatic Neoplasms Protein Kinases Transfection Zebrafish 10.1158/1541-7786.MCR-18-0024 Molecular Cancer Research 16 11 1625-1640 2020-10-27T10:05:14Z 2020-10-27T10:05:14Z 2018 Article Jakhar, R, Luijten, M.N.H, Wong, A.X.F, Cheng, B, Guo, K, Neo, S.P, Au, B, Kulkarni, M, Lim, K.J, Maimaiti, J, Chong, H.C, Lim, E.H, Tan, T.B.K, Ong, K.W, Sim, Y, Wong, J.S.L, Khoo, J.B.K, Ho, J.T.S, Chua, B.T, Sinha, I, Wang, X, Connolly, J.E, Gunaratne, J, Crasta, K.C (2018). Autophagy governs protumorigenic effects of mitotic slippage-induced senescence. Molecular Cancer Research 16 (11) : 1625-1640. ScholarBank@NUS Repository. https://doi.org/10.1158/1541-7786.MCR-18-0024 15417786 https://scholarbank.nus.edu.sg/handle/10635/181172 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031
institution National University of Singapore
building NUS Library
continent Asia
country Singapore
Singapore
content_provider NUS Library
collection ScholarBank@NUS
topic antimitotic agent
antineoplastic agent
autophagy related protein 5
biological marker
chloroquine
hydroxymethylglutaryl coenzyme A reductase kinase
nocodazole
paclitaxel
protein
protein p53
protein PERK
unclassified drug
AMP-activated protein kinase kinase
antineoplastic agent
cytokine
protein kinase
animal experiment
animal model
apoptosis
Article
autophagy
cancer inhibition
carcinogenesis
cell death
cell fate
cell invasion
cell migration
controlled study
DNA damage
endoplasmic reticulum stress
enzyme activation
escape behavior
G1 phase cell cycle checkpoint
gene silencing
human
human cell
human tissue
interphase
microtubule
mitosis
mitosis inhibition
mitotic slippage
mouse
nonhuman
paracrine signaling
phenotype
priority journal
S phase cell cycle checkpoint
senescence
tetraploidy
tumor growth
vascularization
animal
autophagy
Bagg albino mouse
bone tumor
cell aging
colon tumor
drug effect
female
genetic transfection
HCT 116 cell line
HEK293 cell line
MCF-7 cell line
metabolism
mitosis
neoplasm
nude mouse
osteosarcoma
pancreas tumor
pathology
physiology
xenograft
zebra fish
Animals
Antineoplastic Combined Chemotherapy Protocols
Autophagy
Bone Neoplasms
Cellular Senescence
Colonic Neoplasms
Cytokines
Female
HCT116 Cells
HEK293 Cells
Heterografts
Humans
MCF-7 Cells
Mice
Mice, Inbred BALB C
Mice, Nude
Mitosis
Neoplasms
Osteosarcoma
Pancreatic Neoplasms
Protein Kinases
Transfection
Zebrafish
spellingShingle antimitotic agent
antineoplastic agent
autophagy related protein 5
biological marker
chloroquine
hydroxymethylglutaryl coenzyme A reductase kinase
nocodazole
paclitaxel
protein
protein p53
protein PERK
unclassified drug
AMP-activated protein kinase kinase
antineoplastic agent
cytokine
protein kinase
animal experiment
animal model
apoptosis
Article
autophagy
cancer inhibition
carcinogenesis
cell death
cell fate
cell invasion
cell migration
controlled study
DNA damage
endoplasmic reticulum stress
enzyme activation
escape behavior
G1 phase cell cycle checkpoint
gene silencing
human
human cell
human tissue
interphase
microtubule
mitosis
mitosis inhibition
mitotic slippage
mouse
nonhuman
paracrine signaling
phenotype
priority journal
S phase cell cycle checkpoint
senescence
tetraploidy
tumor growth
vascularization
animal
autophagy
Bagg albino mouse
bone tumor
cell aging
colon tumor
drug effect
female
genetic transfection
HCT 116 cell line
HEK293 cell line
MCF-7 cell line
metabolism
mitosis
neoplasm
nude mouse
osteosarcoma
pancreas tumor
pathology
physiology
xenograft
zebra fish
Animals
Antineoplastic Combined Chemotherapy Protocols
Autophagy
Bone Neoplasms
Cellular Senescence
Colonic Neoplasms
Cytokines
Female
HCT116 Cells
HEK293 Cells
Heterografts
Humans
MCF-7 Cells
Mice
Mice, Inbred BALB C
Mice, Nude
Mitosis
Neoplasms
Osteosarcoma
Pancreatic Neoplasms
Protein Kinases
Transfection
Zebrafish
Jakhar, R
Luijten, M.N.H
Wong, A.X.F
Cheng, B
Guo, K
Neo, S.P
Au, B
Kulkarni, M
Lim, K.J
Maimaiti, J
Chong, H.C
Lim, E.H
Tan, T.B.K
Ong, K.W
Sim, Y
Wong, J.S.L
Khoo, J.B.K
Ho, J.T.S
Chua, B.T
Sinha, I
Wang, X
Connolly, J.E
Gunaratne, J
Crasta, K.C
Autophagy governs protumorigenic effects of mitotic slippage-induced senescence
description 10.1158/1541-7786.MCR-18-0024
author2 DUKE-NUS MEDICAL SCHOOL
author_facet DUKE-NUS MEDICAL SCHOOL
Jakhar, R
Luijten, M.N.H
Wong, A.X.F
Cheng, B
Guo, K
Neo, S.P
Au, B
Kulkarni, M
Lim, K.J
Maimaiti, J
Chong, H.C
Lim, E.H
Tan, T.B.K
Ong, K.W
Sim, Y
Wong, J.S.L
Khoo, J.B.K
Ho, J.T.S
Chua, B.T
Sinha, I
Wang, X
Connolly, J.E
Gunaratne, J
Crasta, K.C
format Article
author Jakhar, R
Luijten, M.N.H
Wong, A.X.F
Cheng, B
Guo, K
Neo, S.P
Au, B
Kulkarni, M
Lim, K.J
Maimaiti, J
Chong, H.C
Lim, E.H
Tan, T.B.K
Ong, K.W
Sim, Y
Wong, J.S.L
Khoo, J.B.K
Ho, J.T.S
Chua, B.T
Sinha, I
Wang, X
Connolly, J.E
Gunaratne, J
Crasta, K.C
author_sort Jakhar, R
title Autophagy governs protumorigenic effects of mitotic slippage-induced senescence
title_short Autophagy governs protumorigenic effects of mitotic slippage-induced senescence
title_full Autophagy governs protumorigenic effects of mitotic slippage-induced senescence
title_fullStr Autophagy governs protumorigenic effects of mitotic slippage-induced senescence
title_full_unstemmed Autophagy governs protumorigenic effects of mitotic slippage-induced senescence
title_sort autophagy governs protumorigenic effects of mitotic slippage-induced senescence
publishDate 2020
url https://scholarbank.nus.edu.sg/handle/10635/181172
_version_ 1800914625860993024