Autophagy governs protumorigenic effects of mitotic slippage-induced senescence
10.1158/1541-7786.MCR-18-0024
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sg-nus-scholar.10635-1811722024-04-08T14:38:44Z Autophagy governs protumorigenic effects of mitotic slippage-induced senescence Jakhar, R Luijten, M.N.H Wong, A.X.F Cheng, B Guo, K Neo, S.P Au, B Kulkarni, M Lim, K.J Maimaiti, J Chong, H.C Lim, E.H Tan, T.B.K Ong, K.W Sim, Y Wong, J.S.L Khoo, J.B.K Ho, J.T.S Chua, B.T Sinha, I Wang, X Connolly, J.E Gunaratne, J Crasta, K.C DUKE-NUS MEDICAL SCHOOL MICROBIOLOGY AND IMMUNOLOGY ANATOMY antimitotic agent antineoplastic agent autophagy related protein 5 biological marker chloroquine hydroxymethylglutaryl coenzyme A reductase kinase nocodazole paclitaxel protein protein p53 protein PERK unclassified drug AMP-activated protein kinase kinase antineoplastic agent cytokine protein kinase animal experiment animal model apoptosis Article autophagy cancer inhibition carcinogenesis cell death cell fate cell invasion cell migration controlled study DNA damage endoplasmic reticulum stress enzyme activation escape behavior G1 phase cell cycle checkpoint gene silencing human human cell human tissue interphase microtubule mitosis mitosis inhibition mitotic slippage mouse nonhuman paracrine signaling phenotype priority journal S phase cell cycle checkpoint senescence tetraploidy tumor growth vascularization animal autophagy Bagg albino mouse bone tumor cell aging colon tumor drug effect female genetic transfection HCT 116 cell line HEK293 cell line MCF-7 cell line metabolism mitosis neoplasm nude mouse osteosarcoma pancreas tumor pathology physiology xenograft zebra fish Animals Antineoplastic Combined Chemotherapy Protocols Autophagy Bone Neoplasms Cellular Senescence Colonic Neoplasms Cytokines Female HCT116 Cells HEK293 Cells Heterografts Humans MCF-7 Cells Mice Mice, Inbred BALB C Mice, Nude Mitosis Neoplasms Osteosarcoma Pancreatic Neoplasms Protein Kinases Transfection Zebrafish 10.1158/1541-7786.MCR-18-0024 Molecular Cancer Research 16 11 1625-1640 2020-10-27T10:05:14Z 2020-10-27T10:05:14Z 2018 Article Jakhar, R, Luijten, M.N.H, Wong, A.X.F, Cheng, B, Guo, K, Neo, S.P, Au, B, Kulkarni, M, Lim, K.J, Maimaiti, J, Chong, H.C, Lim, E.H, Tan, T.B.K, Ong, K.W, Sim, Y, Wong, J.S.L, Khoo, J.B.K, Ho, J.T.S, Chua, B.T, Sinha, I, Wang, X, Connolly, J.E, Gunaratne, J, Crasta, K.C (2018). Autophagy governs protumorigenic effects of mitotic slippage-induced senescence. Molecular Cancer Research 16 (11) : 1625-1640. ScholarBank@NUS Repository. https://doi.org/10.1158/1541-7786.MCR-18-0024 15417786 https://scholarbank.nus.edu.sg/handle/10635/181172 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031 |
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antimitotic agent antineoplastic agent autophagy related protein 5 biological marker chloroquine hydroxymethylglutaryl coenzyme A reductase kinase nocodazole paclitaxel protein protein p53 protein PERK unclassified drug AMP-activated protein kinase kinase antineoplastic agent cytokine protein kinase animal experiment animal model apoptosis Article autophagy cancer inhibition carcinogenesis cell death cell fate cell invasion cell migration controlled study DNA damage endoplasmic reticulum stress enzyme activation escape behavior G1 phase cell cycle checkpoint gene silencing human human cell human tissue interphase microtubule mitosis mitosis inhibition mitotic slippage mouse nonhuman paracrine signaling phenotype priority journal S phase cell cycle checkpoint senescence tetraploidy tumor growth vascularization animal autophagy Bagg albino mouse bone tumor cell aging colon tumor drug effect female genetic transfection HCT 116 cell line HEK293 cell line MCF-7 cell line metabolism mitosis neoplasm nude mouse osteosarcoma pancreas tumor pathology physiology xenograft zebra fish Animals Antineoplastic Combined Chemotherapy Protocols Autophagy Bone Neoplasms Cellular Senescence Colonic Neoplasms Cytokines Female HCT116 Cells HEK293 Cells Heterografts Humans MCF-7 Cells Mice Mice, Inbred BALB C Mice, Nude Mitosis Neoplasms Osteosarcoma Pancreatic Neoplasms Protein Kinases Transfection Zebrafish |
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antimitotic agent antineoplastic agent autophagy related protein 5 biological marker chloroquine hydroxymethylglutaryl coenzyme A reductase kinase nocodazole paclitaxel protein protein p53 protein PERK unclassified drug AMP-activated protein kinase kinase antineoplastic agent cytokine protein kinase animal experiment animal model apoptosis Article autophagy cancer inhibition carcinogenesis cell death cell fate cell invasion cell migration controlled study DNA damage endoplasmic reticulum stress enzyme activation escape behavior G1 phase cell cycle checkpoint gene silencing human human cell human tissue interphase microtubule mitosis mitosis inhibition mitotic slippage mouse nonhuman paracrine signaling phenotype priority journal S phase cell cycle checkpoint senescence tetraploidy tumor growth vascularization animal autophagy Bagg albino mouse bone tumor cell aging colon tumor drug effect female genetic transfection HCT 116 cell line HEK293 cell line MCF-7 cell line metabolism mitosis neoplasm nude mouse osteosarcoma pancreas tumor pathology physiology xenograft zebra fish Animals Antineoplastic Combined Chemotherapy Protocols Autophagy Bone Neoplasms Cellular Senescence Colonic Neoplasms Cytokines Female HCT116 Cells HEK293 Cells Heterografts Humans MCF-7 Cells Mice Mice, Inbred BALB C Mice, Nude Mitosis Neoplasms Osteosarcoma Pancreatic Neoplasms Protein Kinases Transfection Zebrafish Jakhar, R Luijten, M.N.H Wong, A.X.F Cheng, B Guo, K Neo, S.P Au, B Kulkarni, M Lim, K.J Maimaiti, J Chong, H.C Lim, E.H Tan, T.B.K Ong, K.W Sim, Y Wong, J.S.L Khoo, J.B.K Ho, J.T.S Chua, B.T Sinha, I Wang, X Connolly, J.E Gunaratne, J Crasta, K.C Autophagy governs protumorigenic effects of mitotic slippage-induced senescence |
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10.1158/1541-7786.MCR-18-0024 |
author2 |
DUKE-NUS MEDICAL SCHOOL |
author_facet |
DUKE-NUS MEDICAL SCHOOL Jakhar, R Luijten, M.N.H Wong, A.X.F Cheng, B Guo, K Neo, S.P Au, B Kulkarni, M Lim, K.J Maimaiti, J Chong, H.C Lim, E.H Tan, T.B.K Ong, K.W Sim, Y Wong, J.S.L Khoo, J.B.K Ho, J.T.S Chua, B.T Sinha, I Wang, X Connolly, J.E Gunaratne, J Crasta, K.C |
format |
Article |
author |
Jakhar, R Luijten, M.N.H Wong, A.X.F Cheng, B Guo, K Neo, S.P Au, B Kulkarni, M Lim, K.J Maimaiti, J Chong, H.C Lim, E.H Tan, T.B.K Ong, K.W Sim, Y Wong, J.S.L Khoo, J.B.K Ho, J.T.S Chua, B.T Sinha, I Wang, X Connolly, J.E Gunaratne, J Crasta, K.C |
author_sort |
Jakhar, R |
title |
Autophagy governs protumorigenic effects of mitotic slippage-induced senescence |
title_short |
Autophagy governs protumorigenic effects of mitotic slippage-induced senescence |
title_full |
Autophagy governs protumorigenic effects of mitotic slippage-induced senescence |
title_fullStr |
Autophagy governs protumorigenic effects of mitotic slippage-induced senescence |
title_full_unstemmed |
Autophagy governs protumorigenic effects of mitotic slippage-induced senescence |
title_sort |
autophagy governs protumorigenic effects of mitotic slippage-induced senescence |
publishDate |
2020 |
url |
https://scholarbank.nus.edu.sg/handle/10635/181172 |
_version_ |
1800914625860993024 |