Autophagy governs protumorigenic effects of mitotic slippage-induced senescence

• Main Authors: Jakhar, R, Luijten, M.N.H, Wong, A.X.F, Cheng, B, Guo, K, Neo, S.P, Au, B, Kulkarni, M, Lim, K.J, Maimaiti, J, Chong, H.C, Lim, E.H, Tan, T.B.K, Ong, K.W, Sim, Y, Wong, J.S.L, Khoo, J.B.K, Ho, J.T.S, Chua, B.T, Sinha, I, Wang, X, Connolly, J.E, Gunaratne, J, Crasta, K.C
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2020
• Subjects: antimitotic agent; antineoplastic agent; autophagy related protein 5; biological marker; chloroquine; hydroxymethylglutaryl coenzyme A reductase kinase; nocodazole; paclitaxel; protein; protein p53; protein PERK; unclassified drug; AMP-activated protein kinase kinase; cytokine; protein kinase; animal experiment; animal model; apoptosis; Article; autophagy; cancer inhibition; carcinogenesis; cell death; cell fate; cell invasion; cell migration; controlled study; DNA damage; endoplasmic reticulum stress; enzyme activation; escape behavior; G1 phase cell cycle checkpoint; gene silencing; human; human cell; human tissue; interphase; microtubule; mitosis; mitosis inhibition; mitotic slippage; mouse; nonhuman; paracrine signaling; phenotype; priority journal; S phase cell cycle checkpoint; senescence; tetraploidy; tumor growth; vascularization; animal; Bagg albino mouse; bone tumor; cell aging; colon tumor; drug effect; female; genetic transfection; HCT 116 cell line; HEK293 cell line; MCF-7 cell line; metabolism; neoplasm; nude mouse; osteosarcoma; pancreas tumor; pathology; physiology; xenograft; zebra fish; Animals; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Bone Neoplasms; Cellular Senescence; Colonic Neoplasms; Cytokines; Female; HCT116 Cells; HEK293 Cells; Heterografts; Humans; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Mitosis; Neoplasms; Osteosarcoma; Pancreatic Neoplasms; Protein Kinases; Transfection; Zebrafish
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/181172
• Institution: National University of Singapore

10.1158/1541-7786.MCR-18-0024