Characterisation of mesothelioma-initiating cells and their susceptibility to anti-cancer agents

• Main Authors: Pasdar E.A., Smits M., Stapelberg M., Bajzikova M., Stantic M., Goodwin J., Yan B., Stursa J., Kovarova J., Sachaphibulkij K., Bezawork-Geleta A., Sobol M., Filimonenko A., Tomasetti M., Zobalova R., Hozak P., Dong L.-F., Neuzil J.
• Other Authors: PHYSIOLOGY
• Format: Article
• Published: 2019
• Subjects: alpha tocopherol succinate; antineoplastic agent; breast cancer resistance protein; CD24 antigen; octamer transcription factor 4; tocopherol; tumor marker; animal cell; animal experiment; animal model; Article; cancer stem cell; cancer susceptibility; carcinogenesis; cell adhesion; cell assay; cell count; cell function; cell structure; cell subpopulation; cells by body anatomy; cellular distribution; controlled study; disease activity; human; human cell; malignant mesothelioma; mesosphere; molecular dynamics; molecular pathology; mouse; nonhuman; phenotype; protein determination; protein function; tumor cell; tumor initiating cell; animal; cancer transplantation; cell proliferation; disease course; drug effects; gene silencing; IC50; lung tumor; mesothelioma; metabolism; mitochondrion; multicellular spheroid; nude mouse; pathology; tumor cell line; tumor invasion; Mus; Animals; Antigens, CD24; Antineoplastic Agents; Biomarkers, Tumor; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Disease Progression; Gene Knockdown Techniques; Humans; Inhibitory Concentration 50; Lung Neoplasms; Mesothelioma; Mice, Nude; Mitochondria; Neoplasm Invasiveness; Neoplasm Transplantation; Neoplastic Stem Cells; Phenotype; Spheroids, Cellular; Tocopherols
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161516
• Institution: National University of Singapore

10.1371/journal.pone.0119549