Antitumor effects of Rapamycin in pancreatic cancer cells by inducing apoptosis and autophagy

• Main Authors: Dai, Z.-J, Gao, J, Ma, X.-B, Kang, H.-F, Wang, B.-F, Lu, W.-F, Lin, S, Wang, X.-J, Wu, W.-Y
• Other Authors: MECHANICAL ENGINEERING
• Format: Article
• Published: MDPI 2020
• Subjects: beclin 1; mammalian target of rapamycin; messenger RNA; protein Bax; protein p53; rapamycin; antineoplastic agent; apoptosis regulatory protein; BECN1 protein, human; cadaverine; dansylcadaverine; membrane protein; target of rapamycin kinase; antineoplastic activity; apoptosis; article; autophagy; Bax gene; beclin 1 gene; cancer cell; cancer inhibition; cell proliferation; cell structure; cell vacuole; cell viability; concentration response; controlled study; dose time effect relation; drug effect; drug mechanism; flow cytometry; gene; gene expression regulation; human; human cell; in vitro study; molecular dynamics; pancreas cancer; protein expression; reverse transcription polymerase chain reaction; transmission electron microscopy; tumor suppressor gene; upregulation; 3T3 cell line; analogs and derivatives; animal; cell shape; drug effects; genetics; metabolism; mouse; pancreas tumor; pathology; tumor cell line; ultrastructure; Mammalia; Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; bcl-2-Associated X Protein; Cadaverine; Cell Line, Tumor; Cell Proliferation; Cell Shape; Flow Cytometry; Humans; Membrane Proteins; Mice; NIH 3T3 Cells; Pancreatic Neoplasms; RNA, Messenger; Sirolimus; TOR Serine-Threonine Kinases; Vacuoles
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/183907
• Institution: National University of Singapore

10.3390/ijms14010273