Antitumor effects of Rapamycin in pancreatic cancer cells by inducing apoptosis and autophagy

10.3390/ijms14010273

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Main Authors:	Dai, Z.-J, Gao, J, Ma, X.-B, Kang, H.-F, Wang, B.-F, Lu, W.-F, Lin, S, Wang, X.-J, Wu, W.-Y
Other Authors:	MECHANICAL ENGINEERING
Format:	Article
Published:	MDPI 2020
Subjects:	beclin 1 mammalian target of rapamycin messenger RNA protein Bax protein p53 rapamycin antineoplastic agent apoptosis regulatory protein BECN1 protein, human cadaverine dansylcadaverine membrane protein target of rapamycin kinase antineoplastic activity apoptosis article autophagy Bax gene beclin 1 gene cancer cell cancer inhibition cell proliferation cell structure cell vacuole cell viability concentration response controlled study dose time effect relation drug effect drug mechanism flow cytometry gene gene expression regulation human human cell in vitro study molecular dynamics pancreas cancer protein expression reverse transcription polymerase chain reaction transmission electron microscopy tumor suppressor gene upregulation 3T3 cell line analogs and derivatives animal cell shape drug effects genetics metabolism mouse pancreas tumor pathology tumor cell line ultrastructure Mammalia Animals Antineoplastic Agents Apoptosis Apoptosis Regulatory Proteins Autophagy bcl-2-Associated X Protein Cadaverine Cell Line, Tumor Cell Proliferation Cell Shape Flow Cytometry Humans Membrane Proteins Mice NIH 3T3 Cells Pancreatic Neoplasms RNA, Messenger Sirolimus TOR Serine-Threonine Kinases Vacuoles
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/183907
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1839072024-04-04T02:35:41Z Antitumor effects of Rapamycin in pancreatic cancer cells by inducing apoptosis and autophagy Dai, Z.-J Gao, J Ma, X.-B Kang, H.-F Wang, B.-F Lu, W.-F Lin, S Wang, X.-J Wu, W.-Y MECHANICAL ENGINEERING beclin 1 mammalian target of rapamycin messenger RNA protein Bax protein p53 rapamycin antineoplastic agent apoptosis regulatory protein BECN1 protein, human cadaverine dansylcadaverine membrane protein messenger RNA protein Bax rapamycin target of rapamycin kinase antineoplastic activity apoptosis article autophagy Bax gene beclin 1 gene cancer cell cancer inhibition cell proliferation cell structure cell vacuole cell viability concentration response controlled study dose time effect relation drug effect drug mechanism flow cytometry gene gene expression regulation human human cell in vitro study molecular dynamics pancreas cancer protein expression reverse transcription polymerase chain reaction transmission electron microscopy tumor suppressor gene upregulation 3T3 cell line analogs and derivatives animal apoptosis autophagy cell shape drug effects genetics metabolism mouse pancreas tumor pathology tumor cell line ultrastructure Mammalia Animals Antineoplastic Agents Apoptosis Apoptosis Regulatory Proteins Autophagy bcl-2-Associated X Protein Cadaverine Cell Line, Tumor Cell Proliferation Cell Shape Flow Cytometry Humans Membrane Proteins Mice NIH 3T3 Cells Pancreatic Neoplasms RNA, Messenger Sirolimus TOR Serine-Threonine Kinases Vacuoles 10.3390/ijms14010273 International Journal of Molecular Sciences 14 1 273-285 2020-11-23T08:59:12Z 2020-11-23T08:59:12Z 2013 Article Dai, Z.-J, Gao, J, Ma, X.-B, Kang, H.-F, Wang, B.-F, Lu, W.-F, Lin, S, Wang, X.-J, Wu, W.-Y (2013). Antitumor effects of Rapamycin in pancreatic cancer cells by inducing apoptosis and autophagy. International Journal of Molecular Sciences 14 (1) : 273-285. ScholarBank@NUS Repository. https://doi.org/10.3390/ijms14010273 1661-6596 https://scholarbank.nus.edu.sg/handle/10635/183907 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ MDPI Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	beclin 1 mammalian target of rapamycin messenger RNA protein Bax protein p53 rapamycin antineoplastic agent apoptosis regulatory protein BECN1 protein, human cadaverine dansylcadaverine membrane protein messenger RNA protein Bax rapamycin target of rapamycin kinase antineoplastic activity apoptosis article autophagy Bax gene beclin 1 gene cancer cell cancer inhibition cell proliferation cell structure cell vacuole cell viability concentration response controlled study dose time effect relation drug effect drug mechanism flow cytometry gene gene expression regulation human human cell in vitro study molecular dynamics pancreas cancer protein expression reverse transcription polymerase chain reaction transmission electron microscopy tumor suppressor gene upregulation 3T3 cell line analogs and derivatives animal apoptosis autophagy cell shape drug effects genetics metabolism mouse pancreas tumor pathology tumor cell line ultrastructure Mammalia Animals Antineoplastic Agents Apoptosis Apoptosis Regulatory Proteins Autophagy bcl-2-Associated X Protein Cadaverine Cell Line, Tumor Cell Proliferation Cell Shape Flow Cytometry Humans Membrane Proteins Mice NIH 3T3 Cells Pancreatic Neoplasms RNA, Messenger Sirolimus TOR Serine-Threonine Kinases Vacuoles
spellingShingle	beclin 1 mammalian target of rapamycin messenger RNA protein Bax protein p53 rapamycin antineoplastic agent apoptosis regulatory protein BECN1 protein, human cadaverine dansylcadaverine membrane protein messenger RNA protein Bax rapamycin target of rapamycin kinase antineoplastic activity apoptosis article autophagy Bax gene beclin 1 gene cancer cell cancer inhibition cell proliferation cell structure cell vacuole cell viability concentration response controlled study dose time effect relation drug effect drug mechanism flow cytometry gene gene expression regulation human human cell in vitro study molecular dynamics pancreas cancer protein expression reverse transcription polymerase chain reaction transmission electron microscopy tumor suppressor gene upregulation 3T3 cell line analogs and derivatives animal apoptosis autophagy cell shape drug effects genetics metabolism mouse pancreas tumor pathology tumor cell line ultrastructure Mammalia Animals Antineoplastic Agents Apoptosis Apoptosis Regulatory Proteins Autophagy bcl-2-Associated X Protein Cadaverine Cell Line, Tumor Cell Proliferation Cell Shape Flow Cytometry Humans Membrane Proteins Mice NIH 3T3 Cells Pancreatic Neoplasms RNA, Messenger Sirolimus TOR Serine-Threonine Kinases Vacuoles Dai, Z.-J Gao, J Ma, X.-B Kang, H.-F Wang, B.-F Lu, W.-F Lin, S Wang, X.-J Wu, W.-Y Antitumor effects of Rapamycin in pancreatic cancer cells by inducing apoptosis and autophagy
description	10.3390/ijms14010273
author2	MECHANICAL ENGINEERING
author_facet	MECHANICAL ENGINEERING Dai, Z.-J Gao, J Ma, X.-B Kang, H.-F Wang, B.-F Lu, W.-F Lin, S Wang, X.-J Wu, W.-Y
format	Article
author	Dai, Z.-J Gao, J Ma, X.-B Kang, H.-F Wang, B.-F Lu, W.-F Lin, S Wang, X.-J Wu, W.-Y
author_sort	Dai, Z.-J
title	Antitumor effects of Rapamycin in pancreatic cancer cells by inducing apoptosis and autophagy
title_short	Antitumor effects of Rapamycin in pancreatic cancer cells by inducing apoptosis and autophagy
title_full	Antitumor effects of Rapamycin in pancreatic cancer cells by inducing apoptosis and autophagy
title_fullStr	Antitumor effects of Rapamycin in pancreatic cancer cells by inducing apoptosis and autophagy
title_full_unstemmed	Antitumor effects of Rapamycin in pancreatic cancer cells by inducing apoptosis and autophagy
title_sort	antitumor effects of rapamycin in pancreatic cancer cells by inducing apoptosis and autophagy
publisher	MDPI
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/183907
_version_	1800914731550113792

Antitumor effects of Rapamycin in pancreatic cancer cells by inducing apoptosis and autophagy

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